Background: MIR-610 has been identified as a tumor suppressor in colorectal cancer (CRC). However, its prognostic value in colorectal cancer remains unclear. The aim of this study was to explore the significance of miR-610 expression in prognosis of colorectal cancer. Methods: The expression of MIR-610 was determined in 209 pairs of CRC samples and the corresponding surrounding non-tumor tissue...

This study aimed at using eXtended finite element method (XFEM) to characterize crack growth through bone's intra-cortical pores. Two techniques were compared using Abaqus: (1) void material properties were assigned to pores; (2) multiple enrichment regions with independent crack-growth possibilities were employed. Both were applied to 2D models of transverse images of mouse bone with differing...

Previous studies have shown that microRNA (miR)-610 is crucial in a variety of biological processes in various types of human cancer cells. However, the role of this microRNA in glioblastoma (GBM) is presently unclear. In this study, the role of miR‑610 in cell proliferation was investigated in GBM. It was demonstrated that miR‑610 expression is markedly downregulated in GBM cells and GBM tissu...

Both 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203; NSC 703786) and 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610; NSC 721648) are antitumor agents with novel mechanism(s). Previous studies have indicated that cytochrome (CYP) P450 1A1 is crucial for 5F-203 activity. In the present study, we investigated the functional role of 2 newly identified CYP P450 enzymes, CYP2S1 and C...

Assessing the strength of soil slopes and investigating the means for increasing their safety against failure are crucial in construction projects involving large soil masses. Slope stability analyses have traditionally been performed using a limit state approach. However, any presence of reinforcement or local heterogeneity necessitates the use of numerical techniques such as finite element an...

This paper presents the results obtained by numerical simulation regarding springback phenomenon of a U-shaped part manufactured from tailor welded stripes. The final shape of the formed part is seriously affected by springback phenomenon. This paper work is trying to prove the important role the metal sheet thickness on the springback effect. The U-shaped part has different springback values f...

-In vivo studies could not detect a positive inotropy of endothelin (ET)-1 as described in in vitro experiments. ET-induced direct positive inotropy, which seems to be mediated by ETB receptors, may be antagonized in vivo by an indirect cardiodepressive effect owing to an ET-induced coronary vasoconstriction via ETA receptors. This study compares the effects of a dose of 1 nmol/kg ET-1 alone on...

Reinforced concrete structures consists of two main components and the behavior of these structures influenced by gender and material properties, in order to investigate the behavior of concrete reinforced beam that most important flexural element in reinforced concrete structures, we chosen High Strength Concrete (HSC) for concrete and GFRP and steel bars for reinforcement. For compare the new...

A network of polymers can imbibe a large quantity of a solvent and swell, resulting in a gel. The swelling process can be markedly influenced by a mechanical load and geometric constraint. When the network, solvent, and mechanical load equilibrate, the gel usually swells by a field of inhomogeneous and anisotropic deformation. We show that this field in the swollen gel is equivalent to that in ...

This article presents two applications of the nonlinear finite element analysis (FEA) using ABAQUS/Standard with a user developed material subroutine Nitinol UMAT from Abaqus West. The analyses are found to agree well with the theoretical prediction and/or experimental measurement. In that first example, FEA predicts the stress-strain response of a superelastic Nitinol device at different Af te...