نتایج جستجو برای: abcg5
تعداد نتایج: 307 فیلتر نتایج به سال:
اهدافبازتوانی قلبی از مهمترین اقدامات جهت اثربخشی عمل جراحی قلب و کاهش عوارض آن در بیماران قلبی- عروقی است. تمرینات ورزشی به سبب کمهزینه و جذاب بودن مشوقی برای شرکت بیماران در این برنامههاست. فعالیت ورزشی روی ترکیبات سلول خونی، بهویژه تعداد گلبولهای سفید خون، سوختوساز، متابولیتها، پپتید و بیان ژن در انواع مختلف اثر دارد؛ لذا، هدف از پژوهش حاضر بررسی اثر هشت هفته تمرین هوازی بربیان ژن ABC...
We describe the clinical, biochemical and molecular genetic features of a Chinese family with sitosterolemia, mainly manifested by hematologic abnormalities. The clinical features of three patients were analyzed. Their plasma sterol levels were measured, and ABCG5 and ABCG8 genes sequenced to search for the causative mutation. The main clinical features of these patients were hemolysis and macr...
هدف از این مطالعه بررسی شش هفته تمرین هوازی با و بدون عصاره بنه (4 هفته، 1 میلی گرم به ازای هر کیلوگرم وزن بدن) روی بیان ژن abcg1، abcg5، ویسفاتین و pyy(3-36) در موش های صحرایی ماده.20 سر موش ماده (6-8 هفته ای 128-158 گرمی) که به طور تصادفی به گروه سالین کنترل، سالین تمرین، بنه کنترل و بنه تمرین تقسیم شدند. گروه های تمرینی به مدت شش هفته (5 روز در هفته، به مدت 60 دقیقه و سرعت 25 متر بردقیقه با ...
BACKGROUND Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upon the genetics of sitosterolemia, ABCG5/sterolin-1 and ABCG8/sterolin-2 are h...
objectives the aim of this study was to examine the effect of flaxseed on gene expression of intestinal transporters: niemann-pick c1 like 1 (npc1l1), atp-cassette binding proteins g5 (abcg5) and g8 (abcg8). methods animals were randomly divided into 3 groups 8 rats in each group: group1; normal diet, group2; diabetic rats, and group3; diabetic rats + 4% (w/w) flaxseed. after one-month rats wer...
Several of the ATP binding cassette (ABC) transporters have recently been shown to play important roles in reverse cholesterol transport (RCT) and prevention of atherosclerosis. In the liver, ABCG5 and ABCG8 have been proposed to efflux sterols into the bile for excretion. ABCG5 and ABCG8 also limit absorption of dietary cholesterol and plant sterols in the intestine. In macrophages, ABCA1 and ...
A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol levels have major impacts on initiation, progression, and regression of CVD. Four members of the ATP-binding cassette (ABC) transporter family play important roles in this modulation. ABCA1 and ABCG1 export excess cellula...
The molecular basis of the processes that control two closely related traits, the absorption of cholesterol from the intestines and plasma plant sterol levels, are only partially understood. The discovery that mutations in two novel hemitransporters, ATP binding cassette transporter G5 (ABCG5) and ABCG8, underlie a rare inborn error in plant sterol metabolism, beta-sitosterolemia, represents a ...
OBJECTIVE A high-saturated fatty acid- and cholesterol-containing (HFHC) diet is considered to be a major risk factor for cardiovascular disease. The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces. METHODS AND RESULTS Experiments were carried out in mice fed a...
Hypercholesterolemia is a metabolic disorder characterized by a high concentration of cholesterol in the blood. Eryngium carlinae is a medicinal plant used to treat lipid diseases. The goal of this work was to evaluate, in a model of hypercholesterolemia in mice, the hypocholesterolemic effect of a hydroalcoholic extract of E. carlinae and its main metabolite, D-mannitol. Biochemical analyses o...
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