PURPOSE Various studies have shown that retinal vessels in patients with diabetes mellitus have a reduced capacity to adapt to changes in perfusion pressure and to stimulation with flickering light. Structural and functional changes in retinal vessels in diabetes could lead to a general reduction of vasodilator and/or vasoconstrictor capacity. To gain more insight into this topic, we compared t...

PURPOSE To correlate morphologic changes in the retinal vasculature with degenerative changes in the neuronal retina of mice lacking 56 amino acids from the N-terminus of the Norrie disease (ND) gene product. METHODS Posterior eye segments of ND mice of different age groups were investigated by light and electron microscopy (EM) and scanning EM of vascular corrosion cast preparations. The res...

The field of medical imaging gains its importance with increase in the need of accurate and efficient diagnosis over a short period of time. Since manual processes are tedious, time consuming and impractical for large data there is a need for automatic processing that helps community health workers. Retinal blood vessel segmentation in diabetic retinopathy plays an important role in diagnosing ...

is the winner of the second prize in the recent Olympus–Current Biology photomicrography competition. The retina has been flat-mounted and stained by indirect immunofluorescence to reveal astrocytes (green) and blood vessels (orange/yellow) that are tightly associated with each other, forming a fine network over the retinal surface. Astrocytes (a type of glial cell) are critical for the develop...

Blood vessel segmentation is important for the analysis of ocular fundus images for diseases affecting vessel caliber, occlusion, leakage, inflammation, and proliferation. We introduce a novel supervised method to evaluate performance of Leung-Malik filters in delineating vessels. First, feature vectors are extracted for every pixel with respect to the response of Leung-Malik filters on green c...

We have developed a computer-aided diagnosis system to detect the abnormalities on retinal fundus images. In Japan, ophthalmologists usually detect hypertensive changes by identifying narrowing arteriolae with a focus on an irregularity. The purpose of this study is to develop an automated method for detecting narrowing arteriolae with a focus on an irregularity on retinal images. The blood ves...

BACKGROUND The exact pathogenetic mechanisms of Coats' disease remain unknown. In this report, we show two cases of Coats' disease that achieved a favorable prognosis with the combined treatment of intravitreal bevacizumab (IVB) injection prior to photocoagulation, although both initially resisted photocoagulation therapy. CASE PRESENTATIONS Case 1 was a 15-year-old boy with initial visual ac...

PURPOSE To present a novel automated method for tracking and detection of retinal blood vessels in fundus images. METHODS For every pixel in retinal images, a feature vector was computed utilizing multiscale analysis based on Gabor filters. To classify the pixels based on their extracted features as vascular or non-vascular, various classifiers including Quadratic Gaussian (QG), K-Nearest Nei...

In this paper we consider the problem of blood vessel segmentation in retinal images. After enhancing the retinal image we use green channel of images for segmentation as it provides better discrimination between vessels and background. We consider the negative of retinal green channel image as a topographical surface and extract ridge points on this surface. The points with this property are l...

Myriads of tiny perivascular drusen were found at histologic examination of the eyes of a 19-year-old patient who had pseudopapilledema and who died of a ruptured intracranial aneurysm. The possibility that they arose from constituents leaking from abnormal blood vessels prompted a review of 53 fluorescein retinal angiograms of patients with optic nerve drusen. As compared to a control group, m...