Acetaminophen toxicity has become a leading cause of both accidental and intentional poisoning, and is now the most common cause of acute liver failure in the United States. Acetaminophen poisoning is thus a significant burden on the health care system and a cause of considerable morbidity and mortality. Tetrathiomolybdate is a fast acting anticopper drug developed for Wilson’s disease. However...

background: acetaminophen (n-acetyl-p aminophenol; apap) is one of the most common types of analgesics. it is also the most common xneobitic reported to poison centers. this study investigates if therapeutic doses of nac can falsely increase coagulation tests, prothrombin time (pt) and bleeding time (bt). ​​ methods: thirty-six apap poisoned patients whose acetaminophen serum concentration were...

Acetaminophen is the most commonly used analgesic-antipyretic medication in the United States. Acetaminophen overdose, a frequent cause of drug toxicity, has been recognized as the leading cause of fatal and non-fatal hepatic necrosis. N-Acetylcysteine is the recommended antidote for acetaminophen poisoning. Despite evidence on the efficacy of N-acetylcysteine for prevention of hepatic injury, ...

BACKGROUND There is an overall paucity of data regarding the outcomes of patients with acetaminophen-associated toxic hepatitis in Taiwan. Therefore, the purpose of this study was to recruit a larger number of patients and to examine the clinical features, the degrees of toxic hepatitis, the physiological markers, and the clinical outcomes after intentional acetaminophen poisoning, and to deter...

PURPOSE The efficacy, safety, and cost issues that should be considered when deciding on the appropriate route of acetylcysteine for the treatment of patients with acetaminophen poisoning are reviewed. SUMMARY Oral and i.v. acetylcysteine appear to be equally effective when given within 8-10 hours of acetaminophen overdose. Anaphylactoid reactions to i.v. acetylcysteine have generally been re...

N-Acetylcysteine (NAC) is the standard antidote treatment for preventing hepatotoxicity caused by acetaminophen (AAP) poisoning. This review summarizes recent evidence of AAP Several alternative intravenous regimens NAC have been suggested to improve patient safety reducing adverse drug reactions and medication errors. A two-bag infusion regimen (200 mg/kg over 4 h, followed 100 16 h) reported ...