The turnover number of acetylcholinesterase is of special interest because the enzyme is thought to be one of the fastest enzymes and because a high speed is a prerequisite for the role of the enzyme in nervous function (1). The earliest value of the turnover number was given by Rothenberg and Nachman sohn (2) in terms of the molecular weight for enzyme obtained from electric eel. The molecular...

BACKGROUND The prescribing cascade model involves the misinterpretation of an adverse reaction to 1 drug and the subsequent, potentially inappropriate prescription of a second drug. We present a new example of the prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs used to manage urinary incontinence. METHODS A population-based retrospective cohort study was carr...

This paper presents preliminary results on the efficacy of acetyl-cholinesterase inhibitors (ChE-I) administered in a population of patients with mild-to-moderate Alzheimer's disease (AD), recruited in the context of an Italian Department of Health supported project (Progetto Cronos). The patients were followed up for a maximum of 21 months. Around 45% of the subjects responded well to the trea...

In this work, deep eutectic solvents (DES-based menthol and cholinium chloride) the ethanol, temperature, times were selected to extract bioactive compounds from rhizome, leaves, flowers Curcuma longa L., using ultrasound-assisted extraction. Analyzes antioxidant, flavonoids, antimicrobial, chelation Fe2+, inhibition of cholinesterase's enzymes, cytotoxicity, genotoxicity in Allium cepa cells p...

The cerebrospinal fluid (CSF) of normal humans contains both true and pseudocholinesterases and choline acetyl transferase (choline acetylase) detectable by radiochemical assay. Elevations of total cholinesterase, pseudocholinesterase, and true cholinesterase occur in brain tumors, meningitis, Guillain-Barre disease, hydrocephalus, and brain abscess. However, the non-specificity and inconstancy...

Aim & objective: The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of Acacia catechu ethanolic seed extract to introduce a new source for management of Alzheimer’s disease. Background: Alzheimer’s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50–60% of dementia...

Anti-cholinesterase insecticides constitute a major portion of modern synthetic pesticides and the assessment of cholinesterase (ChE) inhibition is widely used as a specific biomarker for evaluating the exposure of non-target organisms to these pollutants. However, most studies on this biomarker were developed on vertebrates and among invertebrates, gastropod mollusks are rarely used. Gastropod...

Myasthenia gravis is a disorder of impaired neuromuscular transmission resulting in weakness and abnormal fatigability on exertion, improved by anti-acetyl cholinesterase drugs. A number of drugs are known to exacerbate myasthenia gravis or interfere with neuromuscular transmission. We report a case of D-penicillamine induced myasthenia gravis who developed ptosis, diplopia and easy fatigabilit...