introduction: the purpose of this laboratory study was to evaluate the effect of acidic ph on the sealing ability of calcium-enriched mixture (cem) cement and mineral trioxide aggregate (mta) apical plugs. methods and materials: seventy single-rooted human maxillary anterior teeth were recruited. the teeth were randomly divided into 4 experimental groups ( n =15), and 1 negative and 1 positive ...

statement of problem: tooth-coloured restorative materials are brittle with the major shortcomings of sensitivity to flaws and defects. although various mechanical properties of resin composites have been studied, no fracture toughness test data for nano-hybrid composites under acidic condition for a long period of time has been published. objectives: to compare the fracture toughness (k ic ) o...

Aim: To compare the effects of various levels of acidic pH on surface microhardness of Biodentine.TM Materials and methods: Biodentine was mixed and packed into stainless steel molds (diameter = 5 mm and height = 1.5 mm). Four groups of 10 specimens each were formed and exposed to pH: 7.4, 6.4, 5.4 and 4.4 respectively for 4 days. Vickers microhardness was measured for each of the specimens and...

Solid tumors often develop an acidic environment due to the Warburg effect. The effectiveness of diagnosis and therapy may therefore be enhanced by the design and use of pH-sensitive agents that target acidic tumors. Recently, a novel technology was introduced to target acidic tumors using pH low insertion peptide (pHLIP), a peptide that inserts across cell membranes as an alpha-helix when the ...

UNLABELLED Streptococcus pyogenes is responsible for various diseases. During infection, bacteria must adapt to adverse environments, such as the acidic environment. Acidic stimuli may stimulate S. pyogenes to invade into deeper tissue. However, how this acidic stimulus causes S. pyogenes to manipulate its secretome for facilitating invasion remains unclear. The dynamic label-free LC-MS/MS prof...