We describe a patient with severe pityriasis rubra pilaris in whom extensive extraspinal hyperostoses developed after 13 years of oral retinoid treatment. The most prominent abnormality was a bridging exostosis between the left acetabulum and collum. X-ray examinations of the spine during retinoid therapy showed no abnormalities. During oral retinoid treatment, it is important to ask the patien...

OBJECTIVE In vitro and in vivo models indicate that all-trans retinoic acids influence glucose and lipid metabolism. We aimed to evaluate the effects of chronic treatment with acitretin, an all-trans retinoic acid, on glucose metabolism, lipid profile and adiponectin and resistin levels. DESIGN Ten normoglycemic, normolipemic patients affected with psoriasis vulgaris were studied before and a...

The clinical efficacy of retinoids in benign and malignant skin diseases involving immune mechanisms suggests that they affect the immunologic functions of the epidermis. However, these effects have yet to be demonstrated. The action of vitamin A (retinol) and the synthetic retinoids, isotretinoin, etretinate, acitretin, and arotinoid-free acid have been studied on the lymphocyte proliferation ...

Medical School, The University of Sydney, Camperdown, NSW 2050, Australia We present two patients with elephantiasis nostras verrucosa of the lower limbs which improved with oral acitretin. One patient was young and otherwise well while the other was a diabetic with multiple co-morbidities. The treatment was well tolerated and resulted in flattening of verrucous and hyperkeratotic skin lesions ...

Since 1991, eight cases of pulmonary leak capilary syndrome have been described associated with pustular or erythrodermic psoriasis induced or not by the use of acitretin or sirolimus - being one of the cases, fatal. We report the case of a female patient with diagnosed GPP or von Zumbusch and multiple hospitalizations due to such condition. At that time, the condition was evolving with pulmona...

Acitretin over the last 20 years has proven useful in a number of dermatologic diseases. Evidence of efficacy, side-effect profile, and approach to its use will be reviewed.

Retinoids are nonsteroidal hormonal compounds related to retinol. They were discovered more than 50 years ago and have various biologic effects. The oral retinoids currently used in dermatology have different indications and include isotretinoin, acitretin, bexarotene, and alitretinoin. We present the case of a patient who developed thrombocytopenia that was probably induced by acitretin. The p...

Acitretin (Soriatane®, Neotigason®) is a synthetic retinoid for the treatment of severe forms of psoriasis and disorders of keratinisation. Like other retinoids, acitretin has a teratogenic potential since it affects cellular differentiation and proliferation. With the use of oral isotretinoin (Accutane®, Roaccutane®), malformations involving the central nervous system as well as craniofacial, ...