Actinomycin D stimulated phaseollin production in endocarp tissues of the French bean (Phaseolus vulgaris L.), maximum production being obtained with 25 to 30 micrograms per milliliter of antibiotic. Under these conditions, net incorporation of (3)H-uridine into total cell ribonucleic acid was inhibited by more than 80% over a 6-hour induction period. If allowance was made for a 2-hour lag in t...

Katz, Edward (Rutgers, The State University, New Brunswick, N. J.), Clarence R. Waldron, and Mary Lou Meloni. Role of valine and isoleucine as regulators of actinomycin peptide formation by Streptomyces chrysomallus. J. Bacteriol. 82:600-608. 1961-d-Valine is an effective inhibitor of actinomycin synthesis by Streptomyces chrysomallus; l-valine stimulates actinomycin production and reverses the...

The cortisol induction of the enzyme glutamine synthetase (EC 6.4.1.2) in the embryonic chick neural retina is controlled initially at the transcriptional level, as previously demonstrated by the unique appearance of a 15 S RNA species which codes for a single and identical polypeptide chain of glutamine synthetase. This is found only on polyribosomes of cortisol-treated retinas. Recent experim...

In agreement with previous work it has been found that treatment of chick embryos at an early stage of development with small concentrations of actinomycin D (20-40 x 10~ M) produces abnormalities of the brain, neural tube and somites but allows near normal development of heart and blood islands. Similar effects are produced on quail embryos by even smaller concentrations of actinomycin D (0-8-...

The cortisol induction of the enzyme glutamine synthetase (EC 6.4.1.2) in the embryonic chick neural retina is controlled initially at the transcriptional level, as previously demonstrated by the unique appearance of a 15 S RNA species which codes for a single and identical polypeptide chain of glutamine synthetase. This is found only on polyribosomes of cortisol-treated retinas. Recent experim...

For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data ...