The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction. In the context of hepatological practice, however, ALF refers to a highly specific and rare syndrome, characterised by an acute abnormality of liver blood tests in an individual without underlying chronic liver disease. The di...

Introduction Acute liver failure usually develops in multiple organ dysfunction syndrome and significantly increases the mortality risk in patients after cardiac surgery. Aim To assess the safety and efficacy of extracorporeal liver support in patients with acute liver failure after cardiac surgery. Material and methods We studied 39 adult patients with multiple organ dysfunction syndrome a...

Mild hepatic dysfunction in dengue haemorrhagic fever is not unusual. However, acute liver failure (ALF) is rare. When present, its management according to most current guidelines is supportive and carries a poor prognosis. We present a patient with dengue haemorrhagic fever complicated acute liver failure and hepatic encephalopathy who was successfully treated with N-Acetylcysteine (NAC) leadi...

The liver is accountable for many critical functions within the body and loss of those functions can cause signifi cant damage to the body. Liver disease is a extensive term that covers all aspects that cause the liver to fail to perform its proper functions. Acute liver failure indicates the development of severe acute liver injury with impaired synthetic function without preexisting of clinic...

UNLABELLED  Introduction and aim. Liver disease is associated with cognitive dysfunction also at early stages, and minimal hepatic encephalopathy, affecting 20-70% of patients, is frequently under-recognized. The main purpose of this work was to demonstrate that a substantial number of patients, enrolled due to an acute confusional state in absence of a diagnosis of liver disease, suffers of he...

BACKGROUND/AIMS In patients with severe acute liver dysfunction, i.v. phylloquinone (vitamin K1) may be given to exclude vitamin K deficiency, rather than impaired hepatic synthesis of coagulation factors alone, as the cause of the coagulopathy. However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K1 in such patients. METHODS 49 adults with severe acute live...

INTRODUCTION Renal dysfunction is common in chronic liver disease. The cause of this renal dysfunction is either multi-organ involvement in acute conditions or secondary to advanced liver disease. OBJECTIVES The study was undertaken to assess the renal function in chronic liver diseases and find out the association of alteration of renal function with gradation of liver disease. (assessed by ...

Acute liver failure (ALF), also known as fulminant hepatic failure (FHF), embraces a spectrum of clinical entities characterized by acute liver injury, severe hepatocellular dysfunction, and hepatic encephalopathy. This condition is uncommon but not rare; it affects approximately 2000 to 2800 people annually in the United States, with a mortality of 3.5 per million despite intensive support. Lo...