نتایج جستجو برای: acute lympho
تعداد نتایج: 495784 فیلتر نتایج به سال:
Lymphopenia (< 1Giga/L) detected before initiation of chemotherapy is a predictive factor for death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was investigated and tested either alone or in combination with lymphopenia as a prognostic factor at diagnosis for overall survival (OS) in metastatic breast cancer (MBC) patients. The combinatorial TCR diversity was mea...
Although leukocytes from all 13 acute lymphoblastic ieu kemia patients examined had high terminal deoxynucleoti dyl transferase (terminal transferase) activity (20 to 100 units/mg of cellular DNA, where 1 unit equals 1 nmole of nucleotide polymenized in 1 hr) and those from 21 acute myelocytic leukemia patients had low terminal transferase activity (0.2 to 2 units/mg of cellular DNA), the bone ...
Plexiform neurofibromas are peripheral nerve sheath tumors initiated by biallelic mutation of the NF1 tumor suppressor gene in the Schwann cell lineage. To understand whether neurofibroma formation is possible after birth, we induced Nf1 loss of function with an inducible proteolipid protein Cre allele. Perinatal loss of Nf1 resulted in the development of small plexiform neurofibromas late in l...
The total concentrations of alpha(2) globulin and two of its components, haptoglobin and caeruloplasmin, have been determined in the sera from 78 patients with primary malignant diseases of lympho-reticular tissue (reticuloses). The total alpha(2) globulin fraction was significantly raised only in Hodgkin's disease. The serum haptoglobin was also significantly increased in Hodgkin's disease and...
Enzyme L-asparaginase (L-asparagines amidohydrolase EC 3.5.1.1) has the physiological function of hydrolyzing amide group of the side chain in Lasparagine to produce L-aspartate and ammonia. This spectacular property of the enzyme is utilized in chemotherapeutic treatment of certain kinds of lymphoblastic malignancies, mainly in acute lymphoblastic leukaemia (ALL) and lympho-sarcoma for nearly ...
To reduce the morbidity and mortality associated with unrelated donor bone marrow (BM) transplantation and potentially extend the pool of suitable donors, cryopreserved unrelated donor umbilical cord blood was considered as an alternate source of hematopoietic stem cells for transplantation. Patients with leukemia, BM failure syndrome, or inborn error of metabolism were eligible for a phase I c...
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