1/M Acne conglobata 8 to 0 0.25 60.5 8.1 None None Elevated serum cholesterol, creatinine kinase at last visit, mild cheilitis 2/M Acne fulminans 8 to 2 0.18 55.5 10.0 Oral methylpred nisolone Adapalene gel Transient elevation of serum TG, mild cheilitis 3/F Acne fulminans 8 to 4 0.15 34.8 7.4 Oral prednisolone Clindamycin/ benzoyl-peroxide Transient elevation of serum cholesterol, γ-GT, TG, mi...

Background Acne is very common and can have a substantial impact on wellbeing. Guidelines suggest first-line management with topical treatments, but there little evidence regarding which treatments are most effective. Objectives To identify the effective best tolerated for acne using network meta-analysis. Methods CENTRAL, MEDLINE, Embase World Health Organization Trials Registry were searched ...

Disorders of hyperpigmentation are difficult to treat, particularly in dark-skinned individuals. The goal is to reduce the hyperpigmentation without causing undesirable hypopigmentation or irritation in the surrounding normally pigmented skin. The psychosocial impact caused by these disorders must be considered. Although there are many effective therapeutic modalities available, there are poten...

In recent years, there has been an increase in the proportion of AFA structure acne incidence. The etiopathogenesis disease is multicomponent and not fully elucidated. It assumed that hormonal factors chronic activation innate immunity are involved process against background genetic predisposition, which stimulated by external environmental factors: daily stress, Western-style diet, tobacco use...

Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, microbial flora changes, abnormal keratinization, and inflammation. There are several therapeutic options like topical and systemic retinoids, antibiotics, and systemic hormonal drugs. The topical retinoids a play very important role in the treatment of acne vulgaris. However, their use is limited due ...

The aim of this study was to develop a simple and reliable high-performance chromatographic (HPLC) method for simultaneous analysis of adapalene and benzoyl peroxide in pharmaceutical formulation by response surface methodology (RSM). An optimized mobile phase composed of acetonitrile, tetrahydrofuran and water containing 0.1% acetic acid at a ratio of 25:50:25 by volume was successfully predic...