As is well known, adrenal cortex produces and secrete steroids, which originate from circulating or stored cholesterol. All corticosteroids are synthesized through a series of complicated enzymatic steps from cholesterol (Fig. 1). Corticosteroids are classified into three groups, glucocorticoids, mineralocorticoids and adrenal androgens based on their biological actions. In human adrenal cortex...

a 22-year-old man presented with exertional dyspnea commencing one month prior to his admission. echocardiography revealed a non-homogenous mass, and the pathology examination of the pericardial biopsy was compatible with angiosarcoma.

lipoma is the most common soft tissue tumor but the presence of osseous component within the tumor is quite rare. some studies show that less than 1% of lipomas were ossified. we describe the histological, radiological and diagnostic features of an ossified intramuscular lipoma. to the best of the authors' knowledge, a symptomatic ossified intramuscular lipoma without any cortical erosion and h...

conclusions when itbs was applied over the primary motor cortex, it significantly improved manual dexterity, but had no significant effect on the hand motor imagery ability in ms patients. results itbs group showed a reduction in the time required to complete the 9hpt (mean difference = -3.05, p = 0.002), and an increase in the number of blocks transferred in one minute in the bbt (mean differe...

in this review the role of cerebrospinal fluid (csf) in mammalian cerebral cortex development has been highlighted. many studies have focused on the potential role of the csf in the developmental process. in particular, the cerebral cortex develops from the germinal epithelium adjacent to the csf. csf contains proteins, growth factors and other neurotrophic factors which are important for neura...

objective: this study was conducted to determine the changes in the insular cortex in alcohol dependent subjects, and to compare the same with controls, the associated clinical findings. methods: the study group consisted of 30 subjects with alcohol dependence syndrome (ads) selected randomly from the out patient services of the department of psychiatry of a tertiary care hospital. the control ...

spreading depression (sd), discovered by leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes. sd appears to act through several mechanisms and receptors which have not completely understood. here, we studied the effect of inhibitory system in animal model of sd using immunohistochemistry technique. after imp...

low frequency stimulation (lfs) is a potential alternative therapy for epilepsy. however, it seems that the anticonvulsant effects of lfs depend on its target sites in the brain. thus, the present study was designed to compare the anticonvulsant effects of lfs administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. in control group, rats were kindled in ...

the prefrontal cortex (pfc) plays a central role in processing both normal and pathological affective states and it is among the brain regions most closely associated with stress-related psychopathology in humans. the ventromedial pfc (vmpfc) in particular has been shown to be required for healthy emotional regulation, social function and risk assessment and decision-making. also this region ex...