Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge their ligand regulation or structure is available1–3. Here we report that glucocorticoid stress hormones activate adhesion receptor G3 (ADGRG3; also known as GPR97)4–6, prototypical GPCR. The cryo-electron microscopy structures GPR97–Go complexes bound to the anti-inflammatory drug beclomethasone ste...

Background: Coagulation activity of platelets plays an important role in thrombosis formation, Atherosclerotic plaque establishment and cardiovascular disorders. ASA are using as an anti platelet activity drug for patients with Coronary Artery Disease (CAD). Using of plant extraction as a complementary medicine for these patients (CAD) is mostly recommended by traditional medicine specialist. ...

background: acanthamoeba castellanii is the important cause of amoebic keratitis in iran. the key molecule in pathogene­sis of acanthamoeba keratitis is mannose binding protein (mbp) led to adhesion of amoeba to corneal epithelium. subse­quent to adhesion other cytopathic effects occur. the goal of this study was to identify the molecular characterization of a gene encoding mbp in an iranian is...

Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. dynamics are modulated by matrix proteins, integrins, several cytokines in tumor microenvironment. In this scenario, signaling is activated integrins interferons, which can induce ISG15 gene expression. This encodes a ubiquitin-like protein that functions as modifier via ISGylation system. Furthermore, non-conjugated ac...

The cellulose- and pectin-rich plant cell wall defines structure, mediates defense against pathogens, facilitates adhesion. An adhesion mutant screen of Arabidopsis hypocotyls identified a new allele QUASIMODO2 (QUA2), gene required for pectin accumulation whose mutants have reduced content defects. A suppressor qua2 was also isolated describes null SABRE (SAB), which encodes previously describ...

A bovine tropoelastin cDNA encoding exons 15-36 that includes the elastin-receptor binding site was expressed in Escherichia coli as a fusion protein with Protein A from Staphylococcus aureus. After isolation of the fusion protein by affinity chromatography on Ig-Sepharose, the tropoelastin domain was separated from plasmid-pR1T2T-encoded Protein A (Protein A') by CNBr cleavage. Cell-adhesion a...

Anti-adhesion therapy represents a potentially promising avenue for the treatment and prevention of tuberculosis in a post-antibiotic era. Adhesins are surface-exposed microbial structures or molecules that enable pathogenic organisms to adhere to host surfaces, a fundamental step towards host infection. Although several Mycobacterium tuberculosis adhesins have been identified, it is predicted ...