The adrenal cortex tumors (ACT) include both malignant adrenal cortex cancers and benign masses that can be either secreting, of one of the hormones normally produced in the adrenal cortex or non-secretory. We describe clinical features and laboratory finding of patients with adrenal cortex tumors. This is a case series report. 29 cases of childhood with adrenal cortex tumors treated at the Vie...

To elucidate the relationship between steroidogenic hormones and developing adrenal glands, we investigated the immunolocalization of steroidogenic enzymes in equine fetal adrenal glands during mid-late gestation. Fetal adrenal glands were obtained from three horses at 217, 225 and 235 days of gestation. Steroidogenic enzymes were immunolocalized using polyclonal antisera raised against bovine ...

Veterinarians are often presented with complex adrenal neoplasia cases that have significant intraoperative challenges, which require the skills of an experienced surgeon. Perioperative evaluation and treatment of these patients can be equally challenging, and successful outcomes require a thorough understanding of the tumor types that affect the adrenal glands, as well as an understanding of a...

Corticosteroids are group of hormones with similar chemical formulas which are secreted by adrenal cortex. The very slight differences in molecular structure of various corticosteroids give them very different functions. The hormonal steroids are classified according to their biologic effects as glucocorticoids, which mainly affect intermediary metabolism and the immune system, and mineralocort...

Steroidogenic factor-1 (SF-1), a nuclear receptor transcription factor, has a pivotal role in adrenal and gonadal development in humans and mice. It was previously shown that Sf-1 dosage critically regulates adrenal size and function in mice, while in humans mutation of a single SF-1 allele leads to adrenal and/or gonadal dysgenesis. Recent studies have elucidated the role of an increased SF-1 ...

The adrenal gland comprises the cortex, responsible for the production of steroid hormones, and the medulla, producing the catecholamines norepinephrine and epinephrine. Both of these components can show hyperplastic and neoplastic change. This presentation will outline relevant aspects of normal structure and function. Then, with respect to the adrenal cortex, the various types of hyperplasia ...

Tremendous advances have taken place in our understanding of the function of the adrenal glands in health and in disease. In the last decade biochemists have isolated and synthesized numerous hormones secreted by the cortex, while clinical endocrinologists have applied this knowledge in elucidating the various syndromes associated with adrenal disease. Tests of adrenal function tend to be based...

introduction the dexamethasone test has been widely used for diagnosing hypercortisolism. materials and methods we assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved cushing&apos;s disease. results a statistically highly significant correlation was found (for urine cortisol: r = 0.66, p <0.0...

The adrenal cortical hormone 17-hydroxy-11dehydrocorticosterone, hereinafter called " compound E" (Mason and others, 1938; Reichstein and Shoppee, 1943) has been administered to fourteen patients with severe or moderately severe rheumatoid arthritis. In each case improvement in clinical features and in sedimentation rates began to occur within a few days. When administration of the hormone was ...