the identification of multipotential mesenchymal stem cells (mscs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. this review article focuses on the biology of mscs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering. our current unders...

articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. the scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. cartilage tissue engineering requires 3 components: cells, scaffold, and environment. owning to their ...

helicobacter pylori was the main cause of gastric cancer (gc) in all over the world that results in intestinal- and diffuse-type carcinoma. infection by this bacterium remains chronic for a long time. in vitro studies have highlighted the role of stem cells in gc. h. pylori infection results in tissue injury and the adult/tissue stem cells subsequently start to replace the dead cells. the genet...

Neurodegenerative diseases are the hereditary and sporadic diseases which are characterized by progressive neuronal loss of the nervous system and are emerging as the leading cause of death, disabilities, and a socioeconomic burden due to an increase in life expectancy. There are many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s, disease, amyotrophic lateral...

the increasing prevalence of chronic diseases, e.g., cardiovascular disease, diabetes and neuronal degenerative disease, present a challenge to find more effective therapies. stem cell-based therapy, including embryonic, umbilical cord blood and adult stem cells provides a rational treatment tool for regenerative medicine and has the potential to revolutionize modern therapy. however, there are...

conclusions large amounts of preclinical studies have been made of stem cells and there is an increasing interest to perform these studies within the human population but preclinical studies are insufficient; therefore, much more and efficient studies should be conducted to evaluate the efficacy and safety of stem cells. context musculoskeletal injuries may be painful, troublesome, life limitin...

several sources were introduced for cell therapy after neurotrauma. there are some evidences that quiescent stem cells are located in the various regions of the adult mammalian brain including cortex, hippocampus, amygdala and striatum. but more study is needed to identify the characteristics of these cells. in the present study we investigated the possibility of isolating neural stem cells fro...

background: keratinocyte stem cell is one of the adult stem cells that inhabits the skin and contributes to skin function and renewal. adult stem cells are best defined by their capacity to self-renew, and to maintain tissue function for a long period of time. these findings indicate the importance of these cells for clinical applications including regenerative medicine, tissue engineering and ...