ADRs: adverse drug reactions LTT: lymphocyte transformation test MDH: multiple drug hypersensitivity MDHS: multiple drug hypersensitivity syndrome MP: Mycoplasma pneumoniae PA: particle agglutination SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis Tregs: regulatory T cells INTRODUCTION Many adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS)/toxic epidermal necr...

Adverse drug reactions (ADRs) result in major health problems in the United States in both the inpatient and outpatient setting. ADRs are broadly categorized into predictable (type A and unpredictable (type B) reactions. Predictable reactions are usually dose dependent, are related to the known pharmacologic actions of the drug, and occur in otherwise healthy individuals, They are estimated to ...

Pharmacovigilance plays a consequential role in the surveillance of adverse drug reactions, which is provoked by the drugs used to cure diseases. Adverse drug reactions (ADRs) produce detrimental or undesirable effects to the body after administration of drugs. It has been reported that the number of patients dying because of contrary effects of drugs per year increased upto 2.6-fold. Moreover,...

An Adverse Drug Reaction (ADRs) is still a challenge in modern healthcare, increasing complication of therapeutics, an elderly populace and multimorbidity. Pharmacovigilance the science activities relating to detection, assessment, understanding prevention adverse effects or any other medicine/vaccine related problem. This article having objective evaluating pharmacist perception about ADRs mon...

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Our objective was to investigate the effect of ABCC2 polymorphisms on ADRs caused by VPA in Korean epileptic patients. We examined the association of ABC...

Generally the data on adverse reactions to drugs treatment have been recorded in clinical trials, post-marketing analyses and anecdotal reports; however such data are available only in well developed countries and it might not be an up-to-date. The Thalidomide tragedy around 1962 which resulted in the birth of more than 10,000 malformed children by women who took the drug at the early stage of ...

Introduction: Adverse drug reactions (ADRs) Reporting is provides safety and Improves strength of Drug adverse reaction to the Drug. Such ADR reporting programs encourage surveillance for ADRs, promote the reporting of ADRs and stimulate the education of health professionals regarding potential ADRs. Objective: ADR monitoring is an important part of post marketing surveillance which helps in ge...

With the advancements in Artificial intelligence (AI) and accumulation of healthrelated big data, it has become increasingly feasible commonplace to leverage machine learning technologies analyze clinical omics metadata assess possibility adverse drug reactions or events (ADRs) course discovery. Here, we have described a novel approach that combined drug-induced gene expression profile from Ope...

Adverse drug reactions (ADRs) continue to be a significant contributor to overall attrition statistics in the pharmaceutical industry. ADRs pose a significant health problem since they contribute to patient morbidity and mortality and represent one of the most common causes for pharmaceutical product recalls and black-box warning labels. Of a total of 548 drugs approved in the period from 1975 ...

Ensuring drug efficacy and safety are unremitting challenges for drug manufacturers and public health organizations worldwide. It has been estimated that, when all of the drugs in the market used to treat common diseases are considered, only 25% to 60% of patients exhibit the expected pharmacological response [1], while a small portion of patients could develop adverse reactions (ADRs). ADRs ar...