OBJECTIVE To determine relationships between pre-pregnancy risk factors at first antenatal visit booking and pregnancy outcomes. STUDY DESIGN This was a multicenter, cross-sectional study involving women admitted for singleton delivery from July 1 until October 31 (3 months), 2013, at nine major maternity clinics in Kinshasa, Democratic Republic of Congo. All women were checked for hereditary...

The authors found that the neural cell adhesion molecule (NCAM) is hyposialylated in hereditary inclusion body myopathy (HIBM) muscle, as suggested by its decreased molecular weight by Western blot. This abnormality represented the only pathologic feature differentiating HIBM due to GNE mutations from other myopathies with similar clinical and pathologic characteristics. If further confirmed in...

At a Harben Lecture in London in 1908, German scientist Paul Ehrlich described the ideal drug as a “magic bullet” (Zauberkugel). Such a drug would be aimed precisely at a disease site and would not affect healthy tissues. Today, over 3.5 billion prescriptions are dispensed each year in the United States to manage a broad number of health disorders. Although many drugs are aimed more accurately ...

BACKGROUND Repetitive transcranial magnetic stimulation (rTMS) is emerging as a valuable therapeutic and diagnostic tool. rTMS appears particularly promising for disorders characterized by positive sensory phenomena that are attributable to alterations in sensory cortical excitability. Among these are tinnitus, auditory and visual hallucinations, and pain syndromes. OBJECTIVE Despite studies ...

INTRODUCTION Prostate cancer is the second most common cause of cancer death in American men. For patients with adverse pathologic features, postoperative radiotherapy to prostate bed after radical prostatectomy has been shown in randomized studies to improve many important clinical endpoints including overall survival. In this review article, we distinguish adjuvant radiation treatment (ART) f...

BACKGROUND/AIM We evaluated whether sub-stratifying intermediate-risk (IR) prostate cancer using the Memorial Sloan Kettering Cancer (MSKCC) or Prostate Cancer Risk Stratification (ProCaRS) model predicts for adverse imaging or pathologic features. PATIENTS AND METHODS 56 consecutive IR patients who underwent multi-parametric MRI (mpMRI) and radical prostatectomy (RP) were studied. The differ...

Sleep disordered breathing has been linked to adverse cardiovascular outcomes in the general population. In pregnancy, sleep disordered breathing has also been linked to pathologic disorders that have been associated with long term cardiovascular and metabolic outcomes such as gestational hypertensive disorders and gestational diabetes mellitus. Endothelial dysfunction, sympathetic stimulation ...

endometrial calcification along with ossification is an uncommon clinical entity. most of the cases are asymptomatic or present with secondary infertility. endometrial ossification associated with repeated abortions has been reported very infrequently. here we report a case of endometrial calcification with ossification  due to retained fetal bony tissue in a 38 year old symptomatic female havi...