the affinity of low density lipoprotein(ldl) to its receptor is very important, because most of ldl-uptake pathway is done by the ldl receptor and the change in size of ldl particle and the modification in its components may affect the ldl affinity for its receptor. in this study, the effects of a powerful lipid-soluble antioxidant “ubiquinol-10” have been investigated on the affinity of ldl to...

Invited for this month's cover is the group of Prof. Jörg Eppinger. The cover picture illustrates the concept of using metal-conjugated affinity labels (m-ALs) to convert proteases into well-defined and catalytically active artificial metalloenzymes. For more details, see the Communication on p. 50 ff.

Matrix-bound monoclonal antibodies against urokinase have been used to purify this enzyme by affinity chromatography. In a single-step procedure, urokinase can be isolated from crude preparations with high yield and high purity, and without loss of enzymatic activity.

In the future robots will have to operate autonomously for long periods of time. To achieve this they need to be able to learn directly from their environment without human supervision. The use of clustering methods is one possibility to tackle this challenge. Here we present extensions to affinity propagation, a clustering algorithm proposed by Frey and Dueck [5], which makes it suitable for r...