The objective of this research was determining the effect of the A192G polymorphism in some productive and reproductive traits in Antioquia Holstein cows. To achieve this, the technique PCR-RFLP was used to amplify a segment of 249 bp of the bovine inhibin alpha gene (INHA) which was digested with the restriction enzyme MspI. The effect of the INHA genotypes on the productive and reproductive t...

We examined the distribution of single nucleotide polymorphisms (SNPs) in nitric oxide synthase 2A, monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein-1alpha genes in tuberculosis patients and healthy controls from Mexico. The odds of developing tuberculosis were 2.3- and 5.4-fold higher in carriers of M...

the present study investigated the calpain gene diversity in iranian one-hump camels (120 camels) using pcr-rflp method. three genotypes aa, ag and gg were observed with the frequencies of 0.02, 0.19 and 0.78, respectively. the frequencies of a and g alleles were 0.12 and 0.88, respectively. the chi-squared test didn’t show significant deviations from hardy-weinberg equilibrium (p<0.05). associ...

Introduction: The HPGD gene was associated with some cancers, such as colorectal, breast, prostate, and bladder. However, detailed role of 15-hydroxyprostaglandin dehydrogenase (HPGD) gene remain unclear in prostate cancer. The study was to investigate the correlation between rs8752 that located in the 3'untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and pros...

introduction : cytotoxic t-cell lymphocyte antigen 4 (ctla-4) is a member of the superfamily of immunoglobulins that are mainly expressed by activated t cells. it is established that blockade of ctla-4 receptors leads to the enhancement of an immune response. different polymorphisms of the ctla-4 gene have been described which cause increased susceptibility to various malignancies such as lymph...

Intercellular adhesion molecule‑1 (ICAM‑1) is an important adhesion molecule that has a crucial role in lymphocyte migration and atherosclerosis pathogenesis activation. The aim of the present study was to explore the association between the rs5498 polymorphism of the ICAM‑1 gene and coronary heart disease (CHD). The rs5498 polymorphism of the ICAM‑1 gene was detected using polymerase chain rea...

Genome-wide association studies (GWASs) have identified multiple single nucleotide polymorphisms (SNPs) associated with Kawasaki disease (KD). In this study, we replicated the associations of 10 GWAS-identified SNPs with KD in a Han Chinese population. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression, and cumulative effect of non-risk genotypes were al...

conclusions the results demonstrated significant associations between the il-10 (ag-1089, il-10ca) and il-12 (aa) gene polymorphisms and a highly increased risk of vur. background vesicoureteral reflux (vur) is a common childhood disorder that is characterized by the abnormal movement of urine from the bladder into the ureters or kidneys. objectives the aim of this study was to determine whethe...

OBJECTIVE Cathepsin S (CTSS) is a lysosomal cysteine protease and is predominantly expressed in antigen-presenting cells, which plays an important role in the allergic response. In this study, we explored the association between single nucleotide polymorphisms (SNPs) in the promotor regions in CTSS and risk of asthma. PATIENTS AND METHODS A total of 591 cases and 621 controls were recruited f...

The aim of this study was to investigate the association between four single nucleotide polymorphisms in NR3C1 (Tth111I, BclI, ER22/23EK, and N363S), which encode the glucocorticoid receptor, and asthma susceptibility in patients from the Henan Province of China. Three hundred and twenty-eight patients with asthma and 60 healthy volunteers were recruited to this study. The target SNPs were geno...