Age at onset in Huntington's disease (HD) is variable and is influenced by parental sex, paternal age, and genetic background. Several recent models have tried to explain this variable expressivity by invoking parental imprinting and related aspects of epigenetic inheritance. Some of these mechanisms may result in variable DNA methylation at or near the HD gene. We show here that methylation at...

three generations of women (3570 daughters, 1148 mothers and 131 grandmothers) from tehran, iran have been studied for menarcheal age. the results show that the age of onset of menarche has decreased in the present generation- 13.599, compared to 13.690 and 13.870 years, amount their mothers and grandmothers, respectively. these results, when compared with results obtained concerning the other ...

vitiligo is a disease that results in depigmented areas in the skin. it may develop at any age but the average age at onset is 20 years. association of vitiligo and melanoma has been commonly reported, but malignancies other than melanoma have been rarely associated with vitiligo. we report a 73‑year‑old patient with new onset vitiligo who developed esophageal adenocarcinoma in the following ye...