purpose: to determine the prevalence and determinants of age-related macular degeneration (amd) in a 40-64 year old iranian populationmethods: in a cross-sectional study, 6,311 people were randomly selected from shahroud. for all participants, visual acuity, refraction, slit-lamp examination and fundus photography were conducted under pupil dilation. results: results of this study are based on ...

background: cells have complex network of antioxidant enzymes that protect cells from induced damages by reactive oxygen species (ros). catalase and superoxide dismutase are known for their role as primary protection against oxidative stress. oxidative damage is an important risk factor in age-related macular degeneration disease (amd). for the first time in this study the impact of genetic pol...

Younger and older adults were asked to saccade to an orientation-defined target that was presented alone, with a more central distractor, or with a more peripheral distractor. Both age groups exhibited saccadic averaging that was more pronounced in the central distractor condition, wherein older adults had the larger effect. These results are relevant to questions of oculomotor control and also...

OBJECTIVE To analyse satisfaction and patient preferences on the location where they receive an intravitreal injection. METHOD A survey was conducted with the intention of analysing these patients who attended the macula clinic and have been intervened using an intravitreal injection at least once in the day hospital or in the theatre setting, comparing both locations. RESULTS The majority ...

Macular pigment optical density (MPOD)-assessed using customized heterochromatic flicker photometry (cHFP)-is related to better cognition and brain lutein among adults. However, the reliability of MPOD assessed by cHFP has not been investigated in children. We assessed inter-session reliability of MPOD using modified cHFP. 7-10-year-olds (n = 66) underwent cHFP over 2 visits using 11 examiners....

The results of randomized controlled clinical trials of ranibizumab for the treatment of age-related macular degeneration established a new standard of care with the prospect of improved vision in many patients. Subsequent trials have explored different strategies to increase response rates and reduce treatment frequency. This review analyzes the key clinical trial data for ranibizumab on the b...

SNP-SNP interactions have been receiving increasing attention in understanding the mechanism underlying susceptibility to complex diseases. Though many works have been done for the detection of SNP-SNP interactions, the algorithmic development is still ongoing. In this study, an improved opposition-based learning particle swarm optimization (IOBLPSO) is proposed for the detection of SNP-SNP int...

Age related macular degeneration (AMD) is the leading cause of blindness in the developed countries. Approximately 8 million people in America have AMD and the number of advanced AMD is likely to rise by 50% by year 2020 due to the projected increase in the number of elderly people (Friedman et al., 2004). AMD is a condition of significant morbidity in terms of both physical and mental health (...

Age-Related Macular Degeneration is the leading cause of legal blindness in elderly people in Iceland as well as in the western world. If not addressed this will have a huge impact on the quality of life in the ever increasing elderly population. The etiology remains unknown inspite of a better understanding of the pathogenesis. Our treatment options have therefore been limited in the past. For...