Background: Patients undergoing cardiac surgery are at increased risk of bleeding due to multifactorial coagulopathies. In the present study, we aimed at investigating the changes in platelet count and function during and after surgery as well as determining the association of the platelet dysfunction with bleeding and transfusion requirements in these patients.    Methods: A total o...

This study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. This clinical trial was conducted in the outpatients department of Cardiology, Post graduate Medical Institute, Lady Reading Hospital, Peshawar from 15th October 2007 to 20th December 2007. We included 105 su...

this study aimed to develop an index that can rank welding workplace that associate well with possible health risk of welders.welding fumes health index (wfhi) were developed based on data from case studies conducted in plant 1 and plant 2. personal sampling of welding fumes to assess the concentration of metal constituents along with series of lung function tests was conducted. fifteen metal c...

accurate mapping of geological structures play an important role in the land management, some of which are considered as the origination of wind deposits, dust and aerosols. during the last decades, remote sensing has considerably helped the studies of desert areas especially in change detection of land phenomena. this study aims to study the facies morphology of playa in tabas kavir, based on ...

Protein aggregation is phenomenon wherein protein loses its native structure and aggregates due to the adaption of non-native conformation. Amyloid aggregation formed by the accumulation of various proteins causes many diseases in humans and other organisms. Antioxidants can prevent proteins aggregation. Pulicaria undulata  extract along with phenolic compounds can increase protein stability an...

Understanding the microscopic dispersion and aggregation of nanoparticles at nanoscale media has become an important challenge during the last decades. Nanoscale modeling techniques are the important tools to tackle many of the complex problems faced by engineers and scientists. Making progress in the investigations at nanoscale whether experimentally or computationally has helped understand th...

timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. in the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. we then provided experimental evidence of crystallin aggregation and it...

This study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. This clinical trial was conducted in the outpatients department of Cardiology, Post graduate Medical Institute, Lady Reading Hospital, Peshawar from 15th October 2007 to 20th December 2007. We included 105 su...

A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...

A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...