This study presents a comprehensive cellular atlas describing the ongoing pulmonary immune responses in early stages of diffuse alveolar damage. work indicates vital role hyper-inflammatory fibroblast subset around bronchus, mediating neutrophil infiltration through secreting soluble signaling mediators, thus boosting neutrophilic airway inflammation.

Asthma is a multifactorial, chronic inflammatory disease of the airways. The knowledge that asthma is an inflammatory disorder has become a core fundamental in the definition of asthma. Asthma's chief features include a variable degree of air-flow obstruction and bronchial hyper-responsiveness, in addition to the underlying chronic airways inflammation. This underlying chronic airway inflammat...

Bronchial asthma is a disease characterized by the condition of airway hyper-responsiveness, which serves to produce narrowing of the airway secondary to airway inflammation and/or various spasm-inducing stimulus. Nonspecific bronchoprovocation testing is an important method implemented for the purpose of diagnosing asthma; this test measures the actual degree of airway hyper-responsiveness and...

BACKGROUND An increasing prevalence of allergic diseases, such as atopic dermatitis, allergic rhinitis and bronchial asthma, has been noted worldwide. Allergic asthma strongly correlates with airway inflammation caused by the unregulated production of cytokines secreted by allergen-specific type-2 T helper (Th2) cells. This study aims to explore the therapeutic effect of the airway gene transfe...

Asthma is a chronic inflammatory disorder of the airways which is characterized by recurrent episodes of airway obstruction, associated with airway hyper responsiveness that leads to symptoms of dyspnea, wheezing, chest tightness, and/or coughing. Omega shaped epiglottis is a type of laryngomalacia which is a result of curling on itself of the epiglottis because of shortened aryepiglottic folds.

This paper reviews the basis for bronchoalveolar lavage and lung function tests for the diagnosis of inflammatory airway disease (IAD)—defined as cough, airway mucus, and/or exercise intolerance. It is important to realize that these signs, no matter how subtle, may indicate the presence of lower airway inflammation, airway obstruction, and airway hyper-reactivity, which are inextricably linked...

BACKGROUND Asthma is characterized by airway hyper-responsiveness and variable airflow obstruction, in part as a consequence of hyper-contractile airway smooth muscle, which persists in primary cell culture. One potential mechanism for this hyper-contractility is abnormal intracellular Ca(2+) handling. METHODS We sought to compare intracellular Ca(2+) handling in airway smooth muscle cells fr...