A theoretical model is presented describing the reopening by an advancing air bubble of an initially liquid-filled collapsed airway lined with deformable epithelial cells. The model integrates descriptions of flow-structure interaction (accounting for nonlinear deformation of the airway wall and viscous resistance of the airway liquid flow), surfactant transport around the bubble tip (incorpora...

A cardiorespiratory model incorporating control of the human upper airway during sleep is described. Most previous models have not considered the possibility that the upper airway could be a limiting factor for gas exchange. Our model was developed to predict also certain pathophysiological phenomena in the cardiorespiratory system that characterize heavy snoring or sleep apnea. We started by a...

We present a mathematical airway tree-shape framework where airway trees are compared using geodesic distances. The framework consists of a rigorously defined shape space for treelike shapes, endowed with a metric such that the shape space is a geodesic metric space. This means that the distance between two tree-shapes can be realized as the length of the geodesic, or shortest deformation, conn...

background: it has been shown that inhalation of carbonaceous particulate matter may impair lung function in children. objective: using the carbon content of airway macrophages as a marker of individual exposure to particulate matter derived from fossil fuel, we sought direct evidence for this association. methods: 300 children from puffed rice industrial areas and 300 children from population ...

Recent advances have revealed that during exogenous airway challenge, airway diameters cannot be adequately predicted by their initial diameters. Furthermore, airway diameters can also vary greatly in time on scales shorter than a breath. To better understand these phenomena, we developed a multiscale model that allowed us to simulate aerosol challenge in the airways during ventilation. The mod...

airway remodelling is characterized by the thickening and reorganization of the airways seen in mustard  lung patients. mustard lung is the  general description  for  the  chronic obstructive  pulmonary  disease induced  by  sulfur  mustard(sm). pulmonary  disease was diagnosed as the most important  disorder in individuals that had been exposed to sulfur mustard. sulfur mustard is a chemical w...

Aims. The aim of the study was to compare endotracheal intubation with i-gel and LMA (laryngeal mask airway) supreme supraglottic airway devices in orbital osteosynthesis surgery. Methods. 134 patients undergoing orbital plasty after fracture were enrolled in our study and were randomized into three groups: 43 in the endotracheal intubation group, 42 in the LMA-Supreme group, and 49 patients w...

We recently developed a computational model of an airway embedded in elastic parenchyma (Bates JH, Lauzon AM. J Appl Physiol 102: 1912-1920, 2007) that accurately mimics the time dependence of airway resistance on tidal volume and positive end-expiratory pressure (PEEP) following methacholine injection in normal animals. In the present study, we compared the model predictions of bronchodilation...