The effect of FL 1060, a newly described beta-lactam antibiotic, on three strains of Escherichia coli was studied. The agent showed extraordinarily high activity as judged by conventional titrations, but inoculum size, osmolality of the medium, and length of the incubation period were all found to have a marked effect on the result. Continuous turbidimetric monitoring and microscopical observat...

In the title compound, C10H8O3 (systematic name 3-hy-droxy-methyl-4H-chromen-4-one), the fused-ring system is slightly puckered [dihedral angle between the rings = 3.84 (11)°]. The hy-droxy O atom deviates from the heterocyclic ring by 1.422 (1) Å. In the crystal, inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R 2 (2)(12) loops. The dimers are linked by aromatic π-π stacking ...

This paper describes a novel technique for joining similar and dissimilar metal foils, namely micro clinching with cutting by laser shock forming. A series of experiments were conducted to study the deformation behavior of single layer material, during which many important process parameters were determined. The process window of the 1060 pure aluminum foils and annealed copper foils produced b...

Two nuclear signalling pathways for vitamin D. Nature 1993;361: 657-60. (47) Elstner E, Linker-Israeli M, Umiel T, Le J, Grillier I, Said J, et al. Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cisretinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells. Cancer Res 1996;56: 3570-6. (48) Elstner E, Linker-I...

In the present study, andesite basalt originated from deposit site ?Donje Jarinje?, Serbia, was examined as a potential raw material for high-density ceramics production. The production of included dry milling, homogenization, cold isostatic pressing and sintering in air. To determine optimal processing parameters conducted at 1040, 1050, 1060, 1070 1080?C, afterwards duration varied 30 to 240m...

The hormone 1,25-dihydroxyvitamin D3 (VD) has a potential use as an anti-tumor agent, but its clinical applications are restricted by its strong calcemic activity. This has led to the development of VD analogues with selectively increased growth-inhibitory activity. One of the most potent analogues is KH1060, which is a 20-epi-22-oxa-derivative of VD. In human breast cancer MCF-7 cells, we stud...