The Western Washington Intracoronary Streptokinase randomized trial1 first demonstrated that intracoronary thrombolytic therapy improved survival for patients presenting within 12 hours of symptom onset of acute myocardial infarction (MI). Perhaps equally important, this invasive study demonstrated that in-hospital and long-term survival was greatly improved in patients with patent infarctrelat...

The surgical and anatomical basis for using the colon as a substitute for the esophagus were established in 1911 by Kelling and Vuillet1 and for many years was the technique of choice for esophageal replacement2. Its use is helpful in benign diseases, such as caustic or peptic strictures, and malignancies1,3, especially when the stomach cannot be used, and also in children with congenital anoma...

Atractylodes lancea (Thunb.) DC. (AL) has been proven to be effective in the treatment of coronavirus disease 2019 (COVID-19). In this study, TCMSP, TCMID, OMIM, GeneCards, PharmMapper and SwissTargetPrediction were used collect potential targets for AL against COVID-19. The online STRING analysis platform Cytoscape generating a (protein-protein interaction) PPI network. Autodock software deter...

Intercalated discs are located at the bipolar ends of cardiac myocytes and contain specialized junctions that mechanically and electrically couple cardiac myocytes. These junctions are responsible for maintaining intercellular adhesion while allowing contractile force to be transmitted between adjacent myocytes and ensuring that the heart contracts with a normal rhythm. Approximately 200 known ...

Epidemiological and experimental studies suggest that the in utero environment plays a critical role in the development of adult disease, including cardiovascular disease and hypertension. Intrauterine growth retardation produced by maternal undernutrition or exposure to maternal glucocorticoids during critical periods of organogenesis impairs fetal growth and produces offspring that develop hy...

The physical manifestation of a trait is a constant interplay between one’s genetic makeup and environmental factors. This notion has been substantiated by nutrigenomic studies demonstrating the benefits of nutritional supplements along the continuum between health and disease.1 More importantly, these studies have revealed the plasticity by which the genetic substrate can interact with various...

Developing high-performance high-entropy alloys (HEAs) fabricated by laser additive manufacturing (LAM) is the pursuit of metallic community. In present work, we designed a series [(Al6-xNbx)-(FeCoNi)12]Cr3 HEA compositions using alloying strategy based on cluster-plus-glue-atom model. And their thin-wall-sharped bulks were LAM and post-aging treatment. The effects cracking inhibition microstru...

The fusion of model lipid bilayers containing synthetic amino lipids and the regulation of this fusion by inducing transbilayer asymmetry of these amino lipids via imposed pH gradients are demonstrated. Liposomes of 100 nm diameter consisting of 5 mol% 1,2-dioleoyl-3-(N,N-dimethylamino)propane (AL1) in a mixture of egg phosphatidylcholine (EPC), dioleoylphosphatidylethanolamine (DOPE), and chol...

carotid intima-media thickness (IMT), which is now widely used as an adjunct to traditional cardiovascular risk factors to assess atherosclerotic burden.4 Indeed, several crosssectional studies have demonstrated an association between carotid IMT and the severity of atherosclerosis in the coronary arteries, cerebrovasculature, abdominal aorta and femoral arteries. Furthermore, a prospective stu...

Dear Editor, Female Singaporeans currently have a life expectancy of 84.5 years1 and a lifetime risk of 6.5% of developing breast cancer.2 It is estimated that by the year 2050, 11.2% of the population will be aged more than 80 years.3 One in 16 women will develop breast cancer by the age of 80, and there will potentially be 1500 cases of newly diagnosed breast cancer among octogenarians each y...