context advanced glycation end-products (ages) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients. ages proved to be a marker of negative outcome in both diabetes management and surgical procedures in these patients. the reported role of ages prompted the development of pharmacological inhibitors of their effects, giving ri...

To investigate the possible effects of alagebrium chloride (ALT-711) on oxidative stress (OS) process in aging hearts, we examined the role of ALT-711 in cardiac function and OS in the heart of aging rats. Increased mitochondrial DNA (mtDNA) deletion as well as nearly a twofold increase in advanced glycation end products (AGEs) accumulation were observed in aging heart, whereas only about 50% o...