A study of HLA-A and B antigens in 248 patients with biopsy diagnosed alcoholic liver disease was conducted to examine for a genetic predisposition to alcohol related liver injury. No statistically significant differences were established for 8 HLA-A and 16 HLA-B antigens between normal healthy controls (n = 342) and patients with alcoholic fatty liver (n = 86), alcoholic hepatitis (n = 63), ac...

background: non-alcoholic fatty liver disease (nafld) was one of prevalent problems in general population. it was the most common cause of abnormal liver function tests and may lead to steatohepatitis and cirrhosis. the role of many factors has been known in nafld. in this study, we investigated the correlation of serum magnesium level and nafld after minimizing the role of major confounding fa...

background : the liver is a vital organ that plays an important role in the metabolism of nutritional agents, drugs and hormones,synthesis of various proteins, coagulation factors and maintenance of hemostasis between calcium,and phosphorous. biochemical changes in the skeletal system such as osteopenia and pathologic fractures may follow hepatic failure. this researchevaluates metabolic bone c...

Using hepatic vein catheterization, fractional clearance (K) and hepatic extraction rate (ER) of Indocyanine Green (ICG) and radioisotope particles (RI) were studied in cirrhotic portal hypertension (24 postnecrotic cirrhotics and 25 alcoholic cirrhotics). ICG given intravenously is cleared from blood only by hepatocytes, whereas RI are uptaken by intrahepatic (Kupffer cells) and extrahepatic r...

Background Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced liver injury has markedly increased. Methods We conducted a retrospective ...

Although data are available on the change of expression/activity of drug-metabolizing enzymes in liver cirrhosis patients, corresponding data on transporter protein expression are not available. Therefore, using quantitative targeted proteomics, we compared our previous data on noncirrhotic control livers (n = 36) with the protein expression of major hepatobiliary transporters, breast cancer re...

1. Selenium status and blood levels of other nutrients related to lipid peroxidation were studied in patients with advanced alcoholic liver cirrhosis, in male alcoholics who had been abstinent for at least 1 month and in healthy control subjects. 2. Plasma Se was decreased in alcoholic cirrhosis but not among alcoholics in abstinence. Platelet glutathione peroxidase (EC 1.11.1.9; GSH-Px) activi...

The intestinal absorption of (3H)cholecalciferol was studied in five patients with alcoholic liver disease, six patients with primary biliary cirrhosis, and 15 healthy subjects. The rate of appearance in plasma of (3H)cholecalciferol after oral ingestion and the subsequent appearance of (3H) polar metabolites in the alcoholic subjects were similar to those in the healthy subjects. In subjects w...

The syndrome of cirrhotic cardiomyopathy, first recognized in 1969 but mistakenly presumed to reflect latent alcoholic cardiomyopathy in patients with alcoholic cirrhosis, is now recognized to occur in all forms of cirrhosis, alcoholic and non-alcoholic, and thus is associated with cirrhosis per se. The hallmark of the syndrome is normal or increased ventricular contractility at rest, but depre...

Patients with chronic liver diseases are asymptomatic or have only vague non-specific symptoms. Effective medical treatments for chronic liver disease (before cirrhosis is established) are becoming increasingly available and since abnormal LFTs may be the only indication of this diseases. Aims: comparative study on serum Enzyme levels in various liver diseases. Discussion: serum Alkaline phosph...