Peroxisome proliferator-activated receptor-γ (PPARγ) agonists like pioglitazone (PGZ) are effective antidiabetic drugs, but they induce fluid retention and body weight (BW) gain. Dipeptidyl peptidase IV (DPP IV) inhibitors are antidiabetic drugs that enhance renal Na(+) and fluid excretion. Therefore, we examined whether the DPP IV inhibitor alogliptin (ALG) ameliorates PGZ-induced BW gain. Mal...

A series of 3 experiments were conducted to determine the in vitro and in situ disappearance, preference, and performance of steers consuming increasing concentrations of a novel feedstuff called algae meal (ALG). In Exp. 1 and 2, 3 ruminally cannulated steers (998 ± 103 kg BW) and 4 treatments were utilized: a dry-rolled corn-based diet (CON), or 15% ALG (A15), 30% ALG (A30), or 45% ALG (A45) ...

leishmania antigens are weak immunogens and need to be potentiated by various adjuvants and delivery systems. alginate microspheres as an antigen delivery system and quillaja saponins (qs) as an immunoadjuvant have been used to enhance the immune response against autoclaved leishmania major (alm). microspheres were prepared by an emulsification technique and characterized for size, encapsulatio...

Apoptosis-linked gene-2 (ALG-2) encodes a 22 kDa Ca(2+)-binding protein of the penta EF-hand family that is required for programmed cell death in response to various apoptotic agents. Here, we demonstrate that ALG-2 mRNA and protein are down-regulated in human uveal melanoma cells compared to their progenitor cells, normal melanocytes. The down regulation of ALG-2 may provide melanoma cells wit...

In this paper, we first characterize reflexive one-sided A -submodules U of a unital operator algebra A in B(H ) completely. Furthermore we investigate the invariant subspace lattice Lat R and the reflexive hull Ref R, where R is the submodule generated by rank-one operators in U ; in particular, if L is a subspace lattice, we obtain when the rank-one algebra R of Alg L is big enough to determi...

We consider algorithms for learning functions f : X ! Y , where X and Y are nite, and there is assumed to be no noise in the data. Learning algorithms, Alg, are connected with ?(Alg), the set of prior probability distributions for which they are optimal. A method for constructing ?(Alg) from Alg is given and the relationship between the various ?(Alg) is discussed. Improper algorithms are ident...

abstract background: lymphoproliferative disorders are among the most serious and potentially fatal complications of chronic immunosuppression in kidney transplant recipients. the principle risk factors for development of ptld are the degree of overall immunosuppression and the ebv serostatus of the recipient. in this study, the risk of ptld in kidney transplant recipients who received anti- ly...

Purpose. The antitumor activity of a novel alginate (ALG) polymer-based particle that contained paclitaxel (PTX) was evaluated using human primary breast cancer cells. Materials and Methods. PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-l...

A new microsphere consisting of inorganic mesoporous silica nanoparticles (MSNs) and organic alginate (denoted as MSN@Alg) was successfully synthesized by air-dynamic atomization and applied to the intracellular drug delivery systems (DDS) of liver cancer cells with sustained release and specific targeting properties. MSN@Alg microspheres have the advantages of MSN and alginate, where MSN provi...

In this study, 2-[(Acryloyloxy)ethyl]trimethylammonium chloride was graft polymerized onto chitosan (CS) to form quaternary ammonium CS (QAC) by using ammonium persulfate as a redox initiator. Alginate (ALG) microspheres loaded with a water-soluble macromolecular model drug, blue dextran (BD), were obtained by corporation of coaxial gas-flow method and ionic gelation process. CS and QAC were th...