BACKGROUND Assessing bronchial hyper-responsiveness (BHR) is a main diagnostic criterion of asthma. Provocation testing is not readily available in general practice, but peak expiratory flow (PEF) is. Several guidelines promote the use of PEF variability as a diagnostic tool for BHR. This study tested the agreement between histamine challenge testing and PEF variability, and the consequences fo...

Nickel sulphate more frequently determines allergic dermatitis due to contact (contact eczema); less known are nasal inflammation (rhinitis) and bronchial asthma caused by nickel sulphate. Sporadic cases, often related to patients' work have been reported in the literature. The research described herein refers to 20 patients presenting clear nickel allergy with rhinitis (associated in 11 cases ...

The objective of this study was the evaluation of the usefulness of the nasal challenge test in the diagnosis of allergic respiratory diseases in subjects occupationally exposed to flour. A single-blind, placebo controlled study was conducted in 100 subjects with occupational atopic asthma with rhinitis. The control groups consisted of 20 atopic subjects not sensitized to investigated allergens...

It has been reported that provocation test with the use of inhalant allergens is the most reliable method for confirming the causal allergens in bronchial asthmat ·5l. However, reports on the studies on the significance of molds in childhood bronchial asthma using the inhalation provocation test are few even in Europe and America. Since 1964, the authors have been conduct­ ing skin tests and in...

To improve our understanding of the pathophysiology of chronic allergic asthma, we mimicked natural allergen exposure by giving tiny doses of dust-mite extract (equivalent to estimated daily exposure in a typical bedroom) in three weekly sessions for 4 wk. Nine mild asthmatic adults who were highly sensitive to dust-mite allergen participated in the study. Serial assessments of bronchial reacti...

BACKGROUND We investigated the anti-inflammatory potential of n-3 polyunsaturated fatty acids (PUFA) on specific bronchial inflammation. Allergic asthmatics were challenged using a low-dose allergen provocation model. METHODS Our parallel double-blinded study randomly assigned 23 house dust mite-allergic asthmatics (aged 22-29 years; 13 females, 10 males) to dietary supplementation with eithe...

The aim of this study was to evaluate rhinomanometric responses to nasal allergen provocation in children with allergic rhinitis sensitized to house dust mite. We studied 51 children, aged 6-16 years (mean: 11.5 +/- 2.6 years), with clinical symptoms of perennial allergic rhinitis without asthma and 20 non-atopic healthy controls in the same age range (mean: 11.8 +/- 3.8 years). All of the pati...

Aas, K. (1970). Archives of Disease in Childhood, 45, 221. Bronchial provocation tests in asthma. Bronchial provocation tests are necessary for precise aetiological diagnosis in bronchial asthma. This is illustrated by the results in 9,364 bronchial provocation tests compared with skin tests and nasal tests. The technique of bronchial provocation testing and its interpretation are described in ...

Aas, K. (1970). Archives of Disease in Childhood, 45, 221. Bronchial provocation tests in asthma. Bronchial provocation tests are necessary for precise aetiological diagnosis in bronchial asthma. This is illustrated by the results in 9,364 bronchial provocation tests compared with skin tests and nasal tests. The technique of bronchial provocation testing and its interpretation are described in ...