Background: Allergy is a clinical disorder affecting humans worldwide. Allergenic extracts prepared from natural source materials remain heterogeneous in composition and content, but are regularly used for diagnosis and immunotherapy. Recombinant allergens are suitable candidates to use in place of natural allergens; however, the recombinant allergens should be assessed and compared with the na...

The origin of the word “allergy” is in the Greek words “allos” (strange) and “ergon” (reaction), and it is a concept that was proposed in 1906. Atopic dermatitis, allergic rhinitis and other diseases that are caused by allergies have recently become major problems. The various allergens that exist in the environment are causes of these allergic diseases. There are many types of allergens, inclu...

A considerable number of cDNAs coding for allergens have been isolated and expressed. Structural and immunological similarities between recombinant allergens and natural allergens indicate that a sufficient panel of recombinant allergens can be produced for diagnosis and therapy of allergic diseases. Recent studies document the successful in vitro and in vivo determination of a patient's allerg...

BACKGROUND Predicting the allergenicity of proteins is challenging. We considered the possibility that the properties of the intact protein that may alter the likelihood of being taken up by antigen presenting cells, may be useful adjuncts in predicting allergens and non-allergens in silico. It has been shown that negatively charged acidic proteins are preferentially processed by dendritic cell...

Non-specific lipid transfer proteins (nsLTPs) have recently been identified as plant food allergens. They are good examples of true food allergens, in the sense that they are capable of sensitizing, i.e. inducing specific IgE, as well as of eliciting severe symptoms. This is in contrast with most plant food allergens, which are recognized because of primary sensitization to related inhalant all...

ABSTRACT: Allergic dogs are commonly sensitized to food allergens. We evaluated the use of prick test diagnose allergies in with pruritus and efficacy an exclusion diet based on test. The was performed 10 healthy 34 pruritus, which 25 received for 60 days challenged positive pVAS CADESI-4 were assessed 0, 30, after re-exposure. As a result, two control group reacted single allergen, milk wheat....

Background: Atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. Although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about common food allergens in Iranian children with atopic dermatitis. Objectives: This study was des...

The 3-dimensional structure of an allergen defines the accessible parts on the surface of the molecule or epitopes that interact with antibodies. Mapping the antigenic determinants for IgE antibody binding has been pursued through strategies based on the use of overlapping synthetic peptides, recombinant allergenic fragments or unfolded allergens. These approaches led to the identification of m...

Advances in the techniques used to study allergic patients have allowed us to recognize multiple mistakes made in the past, and thus to avoid prescribing patient immunotherapy treatments that are not fully valid. One of the major achievements has been the molecular diagnosis of allergic diseases. In effect, while in the past we only had gross determinations of specific IgE to pollens, we can no...