Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...

Conjunctivitis, also known as pink eye, is a conjunctival inflammation. It brought on by bacteria, viruses, toxins, and allergies, including coronaviruses, the most frequent reason being allergic conjunctivitis (AC), which exposure to pollutants like pollen, animal hair, or mold. The primary contributor it linkage of immunoglobulin E caused allergens receptors stimulated mast cells. As conseque...

BACKGROUND/AIMS Lodoxamide tromethamine and N-acetyl-aspartyl glutamic acid (NAAGA) are mast cell stabilisers, both of which have been shown to be effective in the treatment of allergic conjunctivitis. The aim of this study was to compare the two compounds in patients with common ocular allergic disorders. METHODS 73 patients participated in a double masked, randomised multicentre study. Diag...

PURPOSE Allergic conjunctivitis is a common condition caused by a mast cell-mediated hypersensitivity reaction to immunoglobulin E-bound allergens. The purpose of this study was to investigate the effect of topical cyclosporine A on the development of mast cell-mediated conjunctivitis in mice. METHODS Allergic conjunctivitis was induced in C57BL/6 mice by topical applications of compound 48/8...

Allergic conjunctivitis (AC),a disorder of the conjunctiva in which an allergic component plays a key role, affects approximately 15-25% of the adult and pediatric population 1-8. Estimates in the literature indicate that the seasonal allergic conjunctivitis (SAC) occurs most frequently, followed by atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC), perennial allergic conjunc...

AIMS Differential diagnosis of allergic conjunctivitis or dry eye is sometimes very difficult to diagnose by symptoms and clinical examination alone, especially in older patients. It was hypothesised that clinically allergic patients who were serum antigen specific IgE negative were candidates for dry eye. METHODS Sixty patients were studied prospectively who were clinically diagnosed with al...

OBJECTIVE Allergic conjunctivitis (AC) is a common condition, especially in childhood. The extent to which it occurs concurrently with or independently from allergic rhinitis (AR) has not been well described. AIM To examine the inter-relationship between rhinitis and conjunctivitis and the epidemiological risk factors for these conditions in a rural UK population. METHODS Cross-sectional st...

PURPOSE The host response to allergens appears to be regulated by specific patterns of local cytokine production. More than 20,000 conjunctival superficial cells were collected with a special brush, a smaller version of the Cytobrush used in cervical cytology, from the upper palpebral conjuntiva. METHODS Samples were obtained by cytology brush from seven patients with allergic conjunctivitis ...

Our previous investigations have shown that Dectin-1 plays a crucial role in allergic conjunctivitis (AC) and the mast cells mediate this allergic reaction. Here, we tried to investigate the possible effects and underlying signal pathway of Dectin-1 on the mast cells in allergic conjunctivitis mice. 30 Balb/c mice were randomly divided into control and AC groups. The mice were immunized with ph...