Contact allergy (CA) is alteration of immune response with readiness to develop an inflammatory reaction against a specific substance of low molecular weight (hapten). The prevalence of CA is estimated at 26-40% among adults, and 21-36% children. A proportion of people with CA will remain asymptomatic, among the rest, the most frequent clinical manifestation is allergic contact dermatitis (ACD)...

Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors display exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase-deficient mice, which have increased le...

Allergic contact dermatitis caused by ranitidine is rare. Most cases of allergic contact dermatitis caused by ranitidine have been related to occupational exposure during the pharmaceutical manufacturing process (1–5). We report a case of allergic contact dermatitis caused by ranitidine hydrochloride (HCl) in a veterinary medicament. Interestingly, there have been two recent reports of allergic...

Allergic Contact Dermatitis (ACD) involves the penetration of an allergen through the skin surface where it acts as a hapten by binding to epidermal proteins and eliciting, a delayed Type IV hypersensitivity reaction 48 to 120 hours after exposure. This immunologic response involves the activation of Th1 cells with the subsequent release of cytokines resulting in the classic inflammatory reaction.

Allergic contact dermatitis is a T cell mediated, antigen-specific inflammatory reaction of the skin due to repeated epicutaneous exposure to antigens. Immunologically it is divided into 2 phases, induction and elicitation phase. During the first phase which is clinically silent, naïve T cells are activated and differentiate into antigen-specific memory T cells. During the elicitation phase, af...

Allergic contact dermatitis (ACD) is a common occupational and environmental health issue. In common with other forms of allergy the disease progresses in two stages; an initial phase during which sensitization is acquired, followed later (after subsequent exposure to the same chemical allergen) by elicitation of a cutaneous inflammatory reaction. The development of skin sensitization is associ...

Introduction: Allergic contact dermatitis is a skin disease representing a type IV immunological reaction, also known as a delayed reaction, according to Gell and Coombs’ classification. It results from hypersensitivity to contact allergens and manifests itself as allergic contact dermatitis skin lesions. This clinical problem mainly affects adults and can be of occupational or non-occupational...

Contact dermatitis is an inflammatory skin condition induced by exposure to an environmental agent. Eczema and dermatitis are used synonymously to denote a polymorphous pattern of skin inflammation characterized at least in its acute phase by erythema, vesiculation and pruritus. Substances responsible for contact dermatitis after single or multiple exposures are non protein chemicals, i.e. hapt...

Although most plants are harmless to the skin, allergic reactions to flora are occasionally seen in dermatology practice. Allergic contact dermatitis caused by plants can occur following airborne exposure to pollen, or after prolonged or repeated contact with the stem, leaves, or sap. Also, patients may react to organisms living on the plant, as the cure for allergic contact dermatitis is avoid...