aortopulmonary window (apw) is a rare congenital malformation. it results from an incomplete division between the ascending aorta and the pulmonary artery. we describe a 26-year-old male, who presented with a grade ii exertional dyspnea and palpitations. echocardiography revealed an apw with an ascending aorta aneurysm. he underwent surgery under cardiopulmonary bypass without aortic cross-clam...

STUDY OBJECTIVE The aim was to make an epidemiological study of major congenital heart defects and to make comparisons between groups of heart defects regarding different epidemiological variables. DESIGN The cases with congenital heart defects were identified from two Swedish registries: the Registry of Congenital Malformations and the Child Cardiology Registry. A classification with nine gr...

Congenital heart diseases are substantially appeared before or after birth. There are two important disease categories which are commonly appeared after birth vascular, congenital heart disease. Right ventricular hypertrophy is one of important congenital heart disease. These abnormalities are related to either structure or function of heart and also found associated to cardiovascular system. I...

The 22q11.2 microdeletion syndrome is one of the common microdeletion syndromes seen among children with Congenital Heart Defects. Population based studies have shown the prevalence of 22q11.2 microdeletion syndrome range from 1 in 4000 to 1 in 6000 live births.1,2 Over 80% of children with 22q11.2 microdeletion syndrome have Congenital Heart Defects.1,3,4 Diagnosis of 22q11.2 microdeletion syn...

background: despite several reports regarding the use of the occlutech figulla® flex septal occluder (offso) in adults, there are few reports on its use in children. we sought to study the result of the transcatheter closure of atrial septal defect (asd) using the offso in children ≤ 12 years. methods: w e enrolled 45 consecutive patients, ranging from 2.5 to 12 years of age, in two large pedia...

background: the transcatheter closure of the atrial septal defect (asd) has become an alternative technique to surgical procedures . the aim of this study was to assess the immediate, short, and intermediate-term results of the transcatheter closure of the secundum asd with the amplatzer septal occluder (aso) in adult iranian patients. methods: between december 2004 and july 2008, the transcath...

1920x1200 abstract: background: down syndrome is the most common chromosomal abnormality due to 21 trisomy that usually is accompany with congenital heart diseases. about fifty present of children with down syndrome have heart defects. this study was designed for the aim of abundance percents of septal heart defects in children with down syndrome at imam reza and imam ali hospitals in kermansha...

The alpha-myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in the myocardium of adult mice. We have produced mice carrying a null mutation of alpha-MyHC by homologous recombination in murine ES cells. Homozygous null animals die between 11 and 12 d in utero of gross heart defects, while alpha-MyHC+/- heterozygotes survive and appear externally normal. The presence of a...

BACKGROUND The actual yield from current screening for clinically significant congenital heart malformations in Dutch child health care is far from optimal. In this study factors that determine the effectiveness of this screening are identified and recommendations for the optimization of the screening programme are formulated. METHODS Eighty-two patients with a clinically significant congenit...