alpha-Tocopherol belongs to the group of vitamin E vitamers. Recent years findings indicate that alpha-tocopherol is more than just a simple fat-soluble anti-oxidant as it was found that it can also regulate gene expression. From all vitamin E vitamers human body preferentially retains alpha-tocopherol, but the reasons for this preference are still elusive. Different studies indicated that huma...

Much data has accumulated supporting a proatherogenic role for oxidized low density lipoprotein (Ox-LDL). Micronutrient antioxidants such as alpha-tocopherol, the principal lipid-soluble antioxidant, assume potential significance because levels can be manipulated by dietary measures without resulting in side effects. Co-incubation of LDL in vitro with alpha-tocopherol inhibits its oxidative mod...

The ability of dietary supplementation with carotenoids to protect chick tissues against oxidative stress in vitro was examined. Male Leghorn chicks were fed on diets supplemented (100 mg supplement/kg diet) with either beta-carotene, zeaxanthin (beta,beta-carotene-3,3'-diol), canthaxanthin (beta,beta-carotene-4,4'-dione) or alpha-tocopherol, or on a control diet, from 1 d old until 37 d of age...

The effect of dietary n-6/n-3 fatty acid ratio on alpha-tocopherol homeostasis was investigated in rats. Animals were fed diets containing fat (17% w/w) in which the n-6/n-3 ratio varied from 50 to 0.8. This was achieved by combining corn oil, fish oil, and lard. The polyunsaturated to saturated ratio and total alpha-tocopherol remained constant in all diets. Results showed that enrichment of n...

Present studies indicate that alpha-tocopherol enhances the efficacy of cisplatin as demonstrated by inoculation of Dalton's lymphoma cells incubated with either cisplatin (5 or 10 microg/ml) alone or cisplatin + alpha-tocopherol (25 or 50 microg/ml) into C3H/He mice. Tumour cells (3 x 10(6) cells/mouse) incubated with cisplatin grow slowly in syngeneic mice as indicated by the late appearance ...

PURPOSE Alpha-Tocopherol is an essential micronutrient acting as an antioxidant in the retina. However, the molecular mechanism of its retinal uptake from the circulating blood remains to be determined. The purpose of this study was to elucidate the contribution of scavenger receptor class B, type I (SR-BI), to the uptake of high-density lipoprotein (HDL)-associated alpha-tocopherol (alpha-toco...

In this study, we asked the question "does alpha-tocopherol supplementation prevent an increase in total plasma cholesterol (TPC) concentration and reduce the deposition of cholesterol in arterial plaques of rabbits fed atherogenic diets?" Isocaloric diets containing 0.1% cholesterol to induce atherosclerosis were enriched in one of three fats: saturated fats (SAT), monounsaturated fats (MONO),...

A relatively simple spectrophotometeric method has been developed for the determination of alpha tocopherol in human plasma. Method is modification of a previous micromethod base on oxidation of alpha tocopherol by ferric chloride. The complex of ferrous ions (generated in this reaction) with bathophenanthroline is determined spectrophotometrically at 536 nm. The absorbance of this colored comp...

objective: diabetes mellitus type 2 is one of the most widespread chronic metabolic diseases. in most cases, this type of diabetes is associated with alterations in levels of some inflammatory cytokines and hormones. considering anti-inflammatory properties of plant extracts rich in ascorbic acid (vitamin c) and alpha-tocopherol (vitamin e), anti-diabetic properties of these two well-known anti...

The effect of alpha-tocopherol on the structure and phase behaviour of 1-palmitoyl-2-oleoyl-phosphatidylcholine was examined by real-time synchrotron X-ray diffraction and freeze-fracture electron microscopic methods. X-ray scattering intensity was recorded from mixed aqueous dispersions of phospholipid with 2.5, 5, 10 and 20 mol% alpha-tocopherol during temperature scans at 3 degrees /min betw...