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Affiliations of authors: Oncology Unit, SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy (VF, GN); Department of Surgical, Oncology and Oral Sciences, Sector of Oral Medicine, Palermo University, Palermo, Italy (GC); University of Tennessee Health Science Center, College of Dentistry, Memphis, TN (CM); DH Oncology, Universit a Campus Bio-Medico, Rome, Italy (DS); Department of N...
We read with interest the recent bronchiectasis review by Whitters and Stockley. The authors provide a comprehensive overview of the changes in the immune response that might favour bacterial colonisation of the lower airways and in a second step initiate the vicious cycle leading to chronic inflammation and recurrent infections. Their description of the innate immune system in the lung include...
During mating behavior the Caenorhabditis elegans male must regulate periodic and prolonged protractor muscle contractions to insert his copulatory spicules into his mate. The protractors undergo periodic contractions to allow the spicules to reattempt insertion if a previous thrust failed to breach the vulva. When the spicule tips penetrate the vulva, the protractors undergo prolonged contract...
1. The effects of KCN and iron salts on oxygen consumption has been studied in the cell of Paramecium caudatum by manometric methods. 2. KCN solutions of strengths from M/200 to M/10,000 have been shown to produce no decrease in oxygen consumption, but have in most cases produced a very slight increase in the respiration rate. 3. The pH values were found to have little or no effect on these res...
Mucus secretions play an important role in the immune system by immobilizing foreign particles and neutralizing invading pathogens. The protective effect of these slippery linings that coat the eyes, airways, and other organs, however, prevents the effective delivery of therapeutics. Benjamin Tang et al. developed a biodegradable nanoparticle that may be able to penetrate thick mucus layers, in...
The mutant h-lysozyme, W64CC65A, with Trp64 and Cys65 replaced by Cys and Ala, respectively, was secreted by yeast and purified. Peptide mapping confirmed that W64CC65A contained a nonnative Cys64-Cys81 bond and three native disulfide bonds. The mutant had 2% of the lytic activity of the wild-type lysozyme. The midpoint concentration of the guanidine hydrochloride denaturation curve, the [D]1/2...
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