alzheimer’s disease (ad) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. the pathological initiation and progression of ad is highly complex and its prevalence is on the rise. in his study, alzheimer's disease was induced with single injection of amyloid-β (aβ) pepti...

BACKGROUND Factors that affect the rate of progression of Alzheimer disease (AD) need to be considered in the clinical trial designs of potential disease-modifying therapies. OBJECTIVE To determine the influence of age on AD course in a clinical trial setting. DESIGN Pooled cohort study from 3 AD clinical trials of 18-month duration conducted by the Alzheimer Disease Cooperative Study group...

Alzheimer is age-related, progressive brain degeneration disease. It destroys memory slowly. The number of people living with AD is increasing as fast as the count of aged population and extension of bad nutrition habits. The main cause of AD is not clearly known, but prior studies noted the importance of inflammation in Tau hyperphosphorylation and failure of microglia to clear AB peptide accu...

-The decrease in hippocampal neurogenesis can lead to development of Alzheimer disease (AD), yet various hypothesis suggest that AD patient have increased neurogenesis in the region 1 of hippocampus proper (CA1 region). Ammon‟s horn (the principle region of Alzheimer‟s pathology) has been found to be involved in neuronal loss however the exact nature of neurogenesis is unknown. Insulin like gro...

More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cas...

Background: Alzheimer’s disease (AD) is the most prevalent degenerative disorder of the brain among elderly individuals. Many studies indicate that oxidative stress is an important pathogenic factor which involves oxidizing macromolecules such as DNA, lipids, and proteins in AD. Green tea is a rich source of antioxidant compounds that can remove radical oxygen species. The purpose of this...

nowadays, many people prefer to use herbal remedies instead of chemical treatments, because of a fewer side effects. it seems that herbal drugs can be useful to neuroinflammation diseases like alzheimer. alzheimer disease (ad) is caused by the oxidative stress and inflammatory compounds such as cytokine and beta-amyloid. it causes learning problems due to damage in cells in the hippocampus area...

people with alzheimer disease (ad) have decreases in brain cell function that may increase their risks as drivers. the changes in brain cells affect memory (at first, short-term memory and then much later, long-term memory) and other thinking functions. in addition, people with early ad, though often very functional in many areas of life, may not be as competent behind the wheel of a car as tho...