Alzheimers disease is the most common form of dementia in adults aged 65 or older. Although many studies have measured the effect of tissue degeneration for subcortical structures such as the hippocampi, amygdala, and the ventricles, little is known about the changes that occur in the architecture of the white matter during the course of this disease. The shape and properties of white-matter st...

The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease. Full-length RAGE, a cell surface-located type I membrane protein, can proteolytically be converted by metalloproteinases ADAM10 and MMP9 into a soluble RAGE form. Moreover, administration of recombinant solubl...

neurodegenerative disorders such as huntingtons disease, alzheimers disease, parkinsons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, friedreichs ataxia, and others are multi-factorial illnesses in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. thus, presently there are no effective cures for these disease...