BACKGROUND: Canine parvovirus (CPV) infection is one ofthe most common causes of infectious gastroenteritis in dogs andis a highly contagious, often fatal disease. The original virus(CPV type 2) has had some mutations since its emergence andnew variants (CPV-2a, 2b and 2c) have been reported from manycountries all around the world. Early diagnosis and treatment canprofoundly affect the disease ...

A novel peptide nucleic acid (PNA)-based array was developed for use in ante-mortem antigenic typing discrimination in dogs with canine parvovirus (CPV). Cyclic benzothiazole-2-sulfonyl PNA monomers were synthesized that recognized GTA (CPV-2) and TAT (CPV-2a, -2b and -2c) at the nt 913-915 positions, and AAT (CPV-2 and CPV-2a), GAT (CPV-2b), and GAA (CPV-2c) at the nt 1276-1278 positions of th...

Canine parvovirus (CPV), first recognized as an emerging virus of dogs in 1978, resulted from a successful cross-species transmission. CPV emerged from the endemic feline panleukopenia virus (FPV), or from a closely related parvovirus of another host. Here we refine our current understanding of the evolution and population dynamics of FPV and CPV. By analysing nearly full-length viral sequences...

background: canine parvovirus (cpv) infection is one ofthe most common causes of infectious gastroenteritis in dogs andis a highly contagious, often fatal disease. the original virus(cpv type 2) has had some mutations since its emergence andnew variants (cpv-2a, 2b and 2c) have been reported from manycountries all around the world. early diagnosis and treatment canprofoundly affect the disease ...

Canine parvovirus belongs to the genus Protoparvovirus, family Parvoviridae. The virion is non-enveloped having icosahedral symmetry of 26nm diameter. It has a single stranded negative sense genome of 5.2 kb in length. This single-stranded virus has a DNA genome and use cellular replication machinery, their rate of nucleotide substitution is closer to that of RNA viruses than to that of double-...

Sequencing and computer analysis of the left (52,283 bp) and right (49,649 bp) variable DNA regions of the cowpox virus strain GRI-90 (CPV-GRI) has revealed 51 and 37 potential open reading frames (ORFs), respectively. Comparison of the structure-function organization of these DNA regions of CPV-GRI with those previously published for corresponding regions of genomes of vaccinia virus, strains ...

Canine parvovirus (CPV) infection is still spread among puppies in the State of Rio de Janeiro, Brazil despite the use of vaccination. The evolution of CPV enteritis depends on the host’s age, general condition, and on preexisting or concurrent parasitic infections. Fifty-two fecal samples collected in puppies up to 6 months old with gastroenteritis from November 2002 to July 2004 were tested f...

Canine parvovirus (CPV) and feline panleukopenia virus (FPV) capsids bind to the transferrin receptors (TfRs) of their hosts and use these receptors to infect cells. The binding is partially host specific, as FPV binds only to the feline TfR, while CPV binds to both the canine and feline TfRs. The host-specific binding is controlled by a combination of residues within a raised region of the cap...

Human cytomegalovirus (CMV) UL54 DNA polymerase (pol) mutants with known patterns of resistance to current antivirals ganciclovir (GCV), foscarnet (FOS), and cidofovir (CDV) were tested for cyclopropavir (CPV) susceptibility by a standardized reporter-based yield reduction assay. Exonuclease and A987G (region V) mutations at codons commonly associated with dual GCV-CDV resistance in clinical is...

BACKGROUND There is no information concerning the genotype of Canine parvovirus (CPV) currently circulating in Henan province, China. Therefore, the aim of the present study was to provide insights into the epidemiology and molecular characterization of CPV circulating in Henan province from 2009 to 2014. RESULTS Nineteen thousand nine hundred seven dogs from pet hospitals in the cities of Lu...