Abstract Background ℽ-Aminobutyric acid (GABA) is a non-proteinaceous amino acid. In the mammalian nervous system, GABA functions as an inhibitory neurotransmitter. The present study focused on screening and optimization of ℽ-aminobutyric yield by lactic bacteria using soymilk basal media. Lactobacillus fermentum ( Lb. ) was isolated from sourdough. qualitative confirmation production observed ...

Alfalfa (Medicago sativa L.) is a widely grown and important forage crop. However, alkali stress detrimental to alfalfa yield nutritional quality. Gamma-aminobutyric acid (GABA) signaling molecule, it participates in responds metabolic regulation related plant growth development stress. In this study, we clarify the effect of spraying seedlings with GABA on tolerance seedlings. We determined th...

Gamma-aminobutyric acid (GABA) has several health-promoting qualities, leading to a growing demand for natural GABA production via microbial fermentation. The GABA-producing abilities of the new Tetragenococcus halophilus (THSK) isolated from commercial soy sauce moromi were proven in this investigation. Under aerobic conditions, isolate produced 293.43 mg/L after 5 days cultivation, compared 2...

BACKGROUND Gamma-aminobutyric acid is a major inhibitory neurotransmitter in mammalian brains, and has several well-known physiological functions. Lactic acid bacteria possess special physiological activities and are generally regarded as safe. Therefore, using lactic acid bacteria as cell factories for gamma-aminobutyric acid production is a fascinating project and opens up a vast range of pro...

gamma-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABA(A) or inhibitory GABA(B) receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.

BackgroundTranscranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) hypothetically modulates cognitive functions by facilitating or inhibiting neuronal activities chiefly in cerebral cortex. The effect of tDCS deeper brain region, basal ganglia-cortical circuit, remains unknown.ObjectiveTo investigate interaction between ?-aminobutyric acid (GABA) concentratio...

Glutamate and γ-aminobutyric acid (GABA) are the two main neurotransmitters in human brain. The balance between their excitatory inhibitory functions is crucial for maintaining brain’s physiological functions. Disturbance of glutamatergic or GABAergic neurotransmission leads to serious health problems including neurodegeneration, affective sleep disorders. Both GABA glutamate involved control s...

Objective: GABAergic system is a target for various groups of medications including sedatives, anxiolytics, muscle relaxants, antidepressants and antiepileptics. Several foods or food ingredients are able to affect the by inhibition γ-aminobutyric acid (GABA) degrading enzymes GABA-transaminase succinate semialdehyde dehydrogenase. The purpose this study investigate inhibitory effects tea (Came...

Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...

This study investigated γ-aminobutyric acid (GABA) formation during natural lactic fermentation of cucumbers. Two lots cucumbers were fermented or acidified in duplicate 4 % sodium chloride (NaCl) brine and analyzed for GABA content over 6 months storage. was present fresh pickling at 0.83 ± 0.16 mM 0.56 0.30 mM, respectively. Additional generated (1.21 0.35 mM) remained stable time further pro...