Border, E. A., Cantrell, A. C., and Kilroe-Smith, T. A. (1976). British Journal of Industrial Medicine, 33, 85-87. The in vitro effect of zinc on the inhibition of human 8-aminolevulinic acid dehydratase by lead. The antagonistic effect of zinc on inhibition of human aminolevulinic acid dehydratase (ALAD) by lead was examined in vitro. The phenomenon was studied at pH 6 5-7 5. Zinc and lead wer...

Border, E. A., Cantrell, A. C., and Kilroe-Smith, T. A. (1976). British Journal of Industrial Medicine, 33, 85-87. The in vitro effect of zinc on the inhibition of human 8-aminolevulinic acid dehydratase by lead. The antagonistic effect of zinc on inhibition of human aminolevulinic acid dehydratase (ALAD) by lead was examined in vitro. The phenomenon was studied at pH 6 5-7 5. Zinc and lead wer...

The activity of delta-aminolevulinic acid (ALA) dehydratase, an enzyme involved in heme biosynthesis, has been shown to increase in Friend virus-transformed murine erythroleukemia (MEL) cells during erythroid differentiation. In this study, the nature of the increase in ALA dehydratase activity in MEL cells was examined using a monospecific antibody directed to the enzyme. A sevenfold increase ...

1. The effect of in vitro glycation on delta-aminolevulinic dehydratase (ALA-D) under several experimental conditions was investigated. When preincubated with 500 mM glucose at 37 degrees C for 20 hr, ALA-D was 80% inactivated and glycated hemoglobin levels were increased more than fourfold. 2. Thiobarbituric acid species were not modified during glycation; therefore ALA-D inactivation cannot b...