background: acute myeloid leukemia (aml) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. in cytogenetically normal aml (cn aml), molecular abnormalities in npm, flt3, cebpa, and baalc genes are observed. initially, high baalc (brain and acute leukemia cytoplasmic gene) expression was introduced in a study on am...

background : acute myeloid leukemia (aml) is a disease in elderly patients, with a mean age of diagnosis of 70 years. we have analyzed the clinicopathology features and experimental variables in aml patients in eastern iran and the correlation between survival and fab subgroups of aml. materials and methods : during 2009 to 2014 in a retrospective study, 98 patients with aml referred to the cli...

Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...

Background:Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer’s disease, the protein could also be considered as a novel marker in diagnosis of dis...

Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increa...

background the induction ofâ  cancers incidence by exogenous agents, such as chemical, radiation and especially research on viruses is an interestedâ  area of active basic subjectsâ  and clinical investigation. prominent researches sounds aâ  high prevalence of hbv marker has been found in patients with leukemia as compared to the general population. methods: presentâ  â study was conducted fro...

Myelodysplastic syndrome (MDS) is characterized by clonal hematopoiesis and impaired differentiation, may develop to acute myeloid leukemia (AML). We explored the mechanism of histone methyltransferase EZH2/EHMT2 during transformation MDS into AML. Expression in patients NHD13 mice was detected. EZH2 EHMT2 were silenced or overexpressed SKM-1 cells. The cell proliferation cycle evaluated. Level...

OBJECTIVE: To determine the frequency of proptosis and associations with demographic, clinical hematological characteristics acute myeloid leukemia (AML) in children. METHODS: This descriptive study was conducted at Combined Military Hospital, Rawalpindi, Pakistan from January 2018 to July 2020. Patients AML between 1-12 years age who presented without orbital granulocytic sarcomas (OGS), selec...

Abstract This translational study aimed at gaining insight into the effects of lenalidomide in acute myeloid leukemia (AML). Forty-one AML patients aged 66 or older Swiss cohort HOVON-103 AML/SAKK30/10 were included. After randomization, they received standard induction chemotherapy with without lenalidomide. Bone marrow biopsies diagnosis and before 2nd cycle obtained to assess therapeutic imp...