Solid-state NMR (ssNMR) spectroscopy has shown its indispensable capability of elucidating atomic level structures and interactions in pharmaceutical studies [1-3]. In the past one decade, it has been utilized to investigate polymorphism of pharmaceutical crystalline compounds and the phase transformations during manufactural processing. These thermodynamic transitions of active pharmaceutical ...

Ion implantation of 60 ke V boron into {100} silicon at medium beam currents (150 ttA) was performed at 300-315 K over the dose range from 1 to 8 X 1016/cm2 • Diffraction contrast and high-resolution phase contrast transmission electron microscopy (TEM) were used on planview and 90· cross-section samples to study the formation of a continuous amorphous layer as a function of increasing dose. Ou...

Nano and femtosecond laser writing are becoming very popular techniques for patterning carbon-based materials, as they are single-step processes enabling the drawing of complex shapes without photoresist. However, pulsed laser writing requires costly laser sources and is known to cause damages to the surrounding material. By comparison, continuous-wave lasers are cheap, stable and provide energ...

The crystalline state of water ice in the Solar System depends on the temperature history of the ice and the influence of energetic particles to which it has been exposed. We measured the infrared absorption spectra of amorphous and crystalline water ice in the 10-50 K and 10-140 K temperature ranges, respectively, and conducted a systematic experimental study to investigate the amorphization o...

Understanding the deformation mechanisms in ceramic materials is crucial for optimizing and implementing next-generation ceramic materials in body and vehicle armor systems. One particularly powerful tool for studying deformation mechanisms is transmission electron microscopy (TEM) of impacted materials. Indentation is useful for studying deformation mechanisms, since this method offers the abi...

Bulk ZrO2 polymorphs generally have an extremely high amorphization tolerance upon low energy ion and swift heavy ion irradiation in which ballistic interaction and ionization radiation dominate the ion–solid interaction, respectively. However, under very high-energy irradiation by 1.33 GeV U-238, nanocrystalline (40–50 nm) monoclinic ZrO2 can be amorphized. A computational simulation based on ...

The aim of this study was to investigate the effects of solid carriers and processing routes on the properties of amorphous solid dispersions of itraconazole. Three solid carriers with a range of surface properties were studied, (1) a mesoporous silicate, magnesium aluminum silicate (Neusilin US2), (2) a nonporous silicate of corresponding composition (Veegum) and (3) a non-silicate, inorganic ...

Based on the framework of long-range empirical formulas, the interatomic potentials were constructed for the Ni-Nb-Mo (fcc-bcc-bcc) and Ni-Zr-Mo (fcc-hcp-bcc) ternary metal systems. Applying the constructed potentials, atomistic simulations were performed to predict the energetically favored glass formation regions (GFRs) in the respective composition triangles of the systems. In addition, the ...

An anisotropic nonlinear elastic model is advanced for crystals belonging to either of two polytypes of boron carbide ceramic. Crystals undergo transformation to an isotropic, amorphous phase upon attainment of a local state-based criterion associated with a loss of intrinsic stability. The model is implemented using the dynamic finite element method, and is demonstrated on a representative vol...