Psychostimulant drugs such as amphetamine are prescribed to increase vigilance, suppress appetite, and treat attention disorders, but they powerfully activate the dopamine system and have serious abuse potential. Repeated psychostimulant exposure induces neuronal plasticity within the mesolimbic dopamine system. Here we present evidence that repeated amphetamine exposure results in a suppressio...

Methylphenidate is a central nervous system stimulant pharmacologically related to amphetamines frequently used in attention deficit hyperactivity disorder (ADHD) and narcolepsy. Haemorrhagic stroke is a rare but well-known potential side-effect of amphetamine abuse, however, cerebral ischaemia has been reported casuistically (Rothrock et al., 1988). Here, we present incidence of a reversible i...

population pattern in guilan province represents a dramatic increase in youth population. regarding high prevalence of substance use among them, its destructive effects and consequences and paucity of previous related studies, this research was performed to determine the prevalence of substance use among students of guilan university of medical sciences (gums). we conducted a cross-sectional st...

BACKGROUND Despite widespread use of methamphetamine and other amphetamine-type stimulants (METH/AMPH), little is known about the long-term medical consequences of METH/AMPH abuse and dependence. Preclinical neurotoxicity findings raise public health concerns that these stimulants may damage dopamine neurons, resulting in dopamine-related disorders such as Parkinson's disease (PD). METHODS A ...

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Sir, Clinicians have depended on antidepressants for years in the management of depressive disorders Drug abuse involving antidepressants is not common, most of them involve agents with amphetamine like proper ties, including amineptine and tranylcypromine.1 Amineptine dependence and tianeptine abuse has been well documented.2 No case report related to dothiepin abuse has been documented till d...

The identification of isomeric drugs is gaining increasing importance in forensics and doping control. Isomers vary terms safety, effectiveness, regulation, particularly for amphetamine-related (ARDs). This study developed validated a pseudo-isocratic UPLC-qTOF-MS analytical method the Amphetamine-related (ARDs) blood following mixed-mode solid-phase extraction (MMSPE). procedure requires 250 ?...

Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JNJ42259152 PET to measure changes in PDE10A availability, secondary to pharmacological alterations in DA release and to investigate whether these are D1- or ...

background: informal employment is common in developing countries, including egypt. this type of employment may have significant consequences on mental health. objectives: to determine the prevalence and risk factors of common mental disorders and substance abuse among temporary hired hospital cleaners. methods: a cross-sectional study was conducted on 242 adult temporary cleaners and 209 perma...

conclusions the results of this study in terms of personality disorders and types of used drugs were in accordance with the previous studies results. it is necessary to design appropriate treatment plans for medical treatment of those with personality disorders. results there was a significant correlation between stimulant use and histrionic personality disorder (p < 0.001) and antisocial and n...