نتایج جستجو برای: amplification factor

تعداد نتایج: 895445  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Nicholas J Szerlip Alicia Pedraza Debyani Chakravarty Mohammad Azim Jeremy McGuire Yuqiang Fang Tatsuya Ozawa Eric C Holland Jason T Huse Suresh Jhanwar Margaret A Leversha Tom Mikkelsen Cameron W Brennan

Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor tyrosine kinases (RTKs). Although most GBMs harbor RTK amplifications, clinical trials of small-molecule inhibitors targeting individual RTKs have been disappointing to date. Activation of multiple RTKs within individual GBMs provides a the...

2017
Haiping Ding Rongchu Zhu Zhenxia Song

Abstract—Local irregular topography has a great impact on earthquake ground motion. For scarp topography, using numerical simulation method, the influence extent and scope of the scarp terrain on scarp's upside and downside ground motion are discussed in case of different vertical incident SV waves. The results show that: (1) The amplification factor of scarp's upside region is greater than tha...

Journal: :Cancer research 1988
L T Malden U Novak A H Kaye A W Burgess

Primary brain tumors of glial origin often overexpress epidermal growth factor receptors (EGF-Rs). This may be associated with amplification of the EGF-R gene. We have examined tissue from 23 glioblastoma multiforme tumors and found amplification and rearrangement of the EGF-R gene in four of these. The cytoplasmic domain of the EGF-R gene was invariably amplified in these four tumors, while th...

Journal: :The Journal of the Acoustical Society of America 2011
Dimitri M Donskoy Benjamin A Cray

Preliminary measurements and numerical predictions reveal that simple, and relatively small, horns generate remarkable amplification of acoustic particle velocity. For example, below 2 kHz, a 2.5 cm conical horn has a uniform velocity amplification ratio (throat-to-mouth) factor of approximately 3, or, in terms of a decibel level, 9.5 dB. It is shown that the velocity amplification factor depen...

Journal: :Zisin (Journal of the Seismological Society of Japan. 2nd ser.) 1957

Journal: :ACM transactions on modeling and performance evaluation of computing systems 2023

Wear leveling techniques in flash-based SSDs aim at distributing the erase cycles as uniformly possible across memory blocks within SSD order to extend its life span. The downside of any wear technique is that it causes additional internal write operations, thereby increasing so-called amplification factor, which equals ratio between total number writes performed and requested by host system. I...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1995
U Lönn S Lönn S Friberg B Nilsson C Silfverswärd B Stenkvist

Amplification of c-erb-B2 is examined in patients with transitional cell bladder carcinoma. In a pilot study we found that the amplification correlated with high tumor grade. Tumor grade is a known prognostic factor. Therefore, we next examined the prognostic value of c-erb-B2 amplification in patients with >16 years of clinical follow-up. The gene copy number was determined, using semiquantita...

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