The role of the brain monoamines in the development of hippocampal kindling was studied. Reserpine markedly facilitated the formation of hippocampal kindling. The high amplitude spike waves in the amygdala and reticular formation appeared earlier in the reserpine treated rats than in the saline injected rats. alpha-Methyl-p-tyrosine did not have any effect on the formation of hippocampal kindli...

Rats were subjected to varying degrees of commissurotomy, followed by implantation of a bipolar electrode into each amygdala. After the kindling of six convulsions at one electrode (primary site), the procedure was applied to the contralateral amygdala (secondary site). Convulsions were observed to develop more rapidly, independent of the degree or kind of transection. After 6 secondary site co...

Developmental PCB exposure impairs hearing and induces brainstem audiogenic seizures in adult offspring. The degree to which this enhanced susceptibility to seizure is manifest in other brain regions has not been examined. Thus, electrical kindling of the amygdala was used to evaluate the effect of developmental exposure to an environmentally relevant PCB mixture on seizure susceptibility in th...

Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuated by drugs which block GABA transmission. Paired-pulse depression was signifi...

Kindling in rats produces enduring behavioral changes that parallel the psychobehavioral disturbances frequently accompanying temporal lobe epilepsy. Some evidence suggests that the site of kindling is an important determinant of the type of behavioral changes observed following kindling, although this variable has not been systematically investigated. In the present experiments, the effects of...

Temporal lobe epilepsy (TLE) is often accompanied by interictal behavioral abnormalities, such as fear and memory impairment. To identify possible underlying substrates, we analyzed long-term synaptic plasticity in two relevant brain regions, the lateral amygdala (LA) and the CA1 region of the hippocampus, in the kindling model of epilepsy. Wistar rats were kindled through daily administration ...

In this study the role of CA1 region of dorsal hippocamus an amygdala kindling rate was investigated by bilateral microinjection of lidocaine into hippocampus.28 rats were divided into four groups.in group I:animals were implanted only with a tripolar electrode into the amygdala but in groups 2-4,two guide cannulaae were also implanted into  the CA1 region of the dorsale hippocampus.two monopol...

PURPOSE Minocycline is known as a chemical with neuroprotective, anti-inflammatory, and antimicrobial properties. In this study, the effects of minocycline on seizures induced by amygdala kindling in rats were studied. METHODS Kindled Wistar rats were injected intraperitoneally with saline and, on the following day, with minocycline (50, 25, and 12.5mg/kg for the three groups (1-3), respectiv...

a b s t r a c t introduction: epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures. although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. new medications with novel mechanisms of action are needed to help those patients whose seizures are resistant to...