نتایج جستجو برای: anaplastic large cell lymphoma

تعداد نتایج: 2633619  

Journal: :Nature Reviews Drug Discovery 2012

Journal: :Iberoamerican journal of medicine 2022

Breast is an uncommon site of extra nodal lymphoma accounting for 2.2% all lymphomas. B cell lymphomas are more common than T types. The most subtype Diffuse Large Cell Lymphoma. very challenging to diagnose as it has nonspecific clinical and radiological features. We report a rare case primary in 20-year-old female. It was misdiagnosed abscess on ultrasound suppurative mastitis fine needle asp...

Journal: :Baylor University Medical Center Proceedings 2015

2011
Jean-Loup Huret

Note Anaplastic large cell lymphoma can be classified into: 1Primary systemic ALK+ ALCL, 2Primary systemic ALKALCL, 3Primary cutaneous ALCL (see in paragraph Pathology). The 2 first categories are defined according to the involvement (or not) of ALK in fusion proteins with various partners (see below); ALK+ ALCL cases are sometimes called ALK lymphomas, or ALKomas. ALK+ ALCL can be further divi...

Journal: :Haematologica 2013
Ilske Oschlies Jasmin Lisfeld Laurence Lamant Atsuko Nakazawa Emanuele S G d'Amore Ulrika Hansson Konnie Hebeda Ingrid Simonitsch-Klupp Jadwiga Maldyk Leonhard Müllauer Marianne Tinguely Markus Stücker Marie-Cecile Ledeley Reiner Siebert Alfred Reiter Laurence Brugières Wolfram Klapper Wilhelm Woessmann

Anaplastic large cell lymphomas are peripheral T-cell lymphomas that are characterized by a proliferation of large anaplastic blasts expressing CD30. In children, systemic anaplastic large cell lymphomas often present at advanced clinical stage and harbor translocations involving the anaplastic lymphoma kinase (ALK) gene leading to the expression of chimeric anaplastic lymphoma kinase (ALK)-fus...

Journal: :Haematologica 2013
Maria Joosten Volkhard Seitz Karin Zimmermann Anke Sommerfeld Erika Berg Dido Lenze Ulf Leser Harald Stein Michael Hummel

A characteristic feature of anaplastic large cell lymphoma is the significant repression of the T-cell expression program despite its T-cell origin. The reasons for this down-regulation of T-cell phenotype are still unknown. To elucidate whether epigenetic mechanisms are responsible for the loss of the T-cell phenotype, we treated anaplastic large cell lymphoma and T-cell lymphoma/leukemia cell...

Journal: :Haematologica 2011
Mona Anand Raymond Lai Pascal Gelebart

BACKGROUND The role of β-catenin in cancer has been most studied in tumors of epithelial cell origin. The functional status and biological significance of this protein in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is unknown. DESIGN AND METHODS ALK-positive anaplastic large cell lymphoma cell lines and patients' tumor samples were examined for status of β-catenin...

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