373 ABSTRACT E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstrate that anchorage-independent ILC cells show an increase in nuclear p120, which resu...

Maxillary protraction headgear has been used in the treatment of Class III malocclusion with maxillary deficiency. However, loss of dental anchorage has been reported with tooth-borne anchorage such as lingual arches and expansion devices. This side effect can be minimized with skeletal anchorage devices such as implants, onplants, mini-implants, and miniplates. The use of miniplates for maxill...

E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstrate that anchorage-independent ILC cells show an increase in nuclear p120, which results in relief...

OBJECTIVES Loosening and loss rates of monocortical mini-implants are relatively high, therefore the following null hypothesis was tested: 'The local bone stress in mono and bicortically-anchored mini-implants is identical'. MATERIAL AND METHODS Anisotropic Finite Element Method (FEM) models of the mandibular bone, including teeth, periodontal ligaments, orthodontic braces, and mini-implants ...

I molar-distalization appliances that require little or no patient compliance—including the Pendulum, Distal Jet, and sliding jigs1-3— have been developed as alternatives to headgear. To avoid the anchorage loss that often occurs with these devices, skeletal anchorage has increasingly been employed,4-6 leading to the introduction of new systems. This article introduces the EZ Slider* sliding au...

We have developed methodology to identify the block to anchorage-independent growth and position it within the fibroblast cell cycle. Results with NRK fibroblasts show that mitogen stimulation of the G0/G1 transition and G1-associated increases in cell size are minimally affected by loss of cell anchorage. In contrast, the induction of G1/S cell cycle genes and DNA synthesis is markedly inhibit...

Palatal implants have been used over the last two decades to eliminate headgear wear and to establish stationary anchorage. In this case report, the stability of a palatal implant for distalization of molars bodily and for anchorage maintenance was assessed. The implant was a stepped screw titanium (4.5 mm diameter x 8 mm length), and it was placed in the palatal region for orthodontic purposes...

BACKGROUND Orthodontic protraction of mandibular molars without maxillary counterbalance extraction in cases of aplasia or extraction requires stable anchorage. Reinforcement may be achieved by using either temporary anchorage devices (TAD) or a fixed, functional appliance. The objective was to compare the clinical effectiveness of both methods by testing the null-hypothesis of no significant d...

Evidence is emerging that the closely related ROCK1 and ROCK2 serine/threonine kinases support the invasive and metastatic growth of a spectrum of human cancer types. Therefore, inhibitors of ROCK are under preclinical development. However, a key step in their development involves the identification of genetic biomarkers that will predict ROCK inhibitor antitumor activity. One identified mechan...

AIM To assess if mandibular incisor proclination and protrusion during treatment with the Herbst/multibracket appliance can be prevented through simple screws (MIs) anchorage. MATERIAL AND METHODS After a statistical power analysis, 12 Herbst patients with MIs (100% MIs survival) ligated to the Herbst/multibracket appliance to reinforce anchorage were investigated. A control group matched for...