The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property o...

We discuss several aspects of the cosmological evolution of moduli fields in heterotic string/M-theory scenarios. In particular we study the equations of motion of both the dilaton and overall modulus of these theories in the presence of an expanding Universe and under different assumptions. First we analyse the impact of their couplings to matter fields, which turns out to be negligible in the...

Introduction Whether atherosclerosis is increased or not in Familial Mediterranean Fever (FMF) is a much debated issue. Carotid artery intima media thickness (IMT) a surrogate marker for subclinical atherosclerosis is found to be increased in a number of studies [1-5], however this contrasts with the lack of increased frequency of atherosclerotic plaques[1-5]. Also, population surveys do not in...

the purpose of this study was to investigate the effect of additives, poly(ethylene glycol) (peg) 1450, poloxamer 407, polyvinyl alcohol (pva) and sodium chloride in order to improve physico-chemical characteristics, encapsulation efficiency and in vitro release of bovine serum albumin, form poly(d,l-lactic-co-glycolic acid) (plga) microparticles prepared by the w/o/w solvent evaporation method...

Supraphysiological increases in serum triglycerides and cholesterol often occur during pregnancy, but their effects on vascular function are poorly understood. Intraperitoneal injection of the nontoxic surfactant poloxamer 407 (P-407) results in sustained elevation of triglycerides and cholesterol. We asked if P-407-induced hyperlipidemia during late pregnancy adversely affects mesenteric resis...

We consider the construction of inverted hybrid inflation models in which the vacuum energy during inflation is at the TeV scale, and the inflaton couples to the Higgs field. Such models are of interest in the context of some recently proposed models of electroweak baryogenesis. We demonstrate how constraints on these models arise from quantum corrections, and how selfconsistent examples may be...

Poloxamer 407 (P-407) is a copolymer surfactant that induces a dose-controlled dyslipidemia in both mice and rats. Human macrophages cultured with P-407 exhibit a concentration-dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1) linked to downregulation of the ATP-binding cassette transporter A1 (ABCA1). Activators of peroxisome proliferator-activated receptor gamma (PPARg), ...

In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407-PL 188 hydrogels containing tramadol (...

Agility is a theme which arises in relation to a range of endeavours in the military and the non-military world, appearing either in accounts of practical experience or in statements of aspirations. Concepts of agility have recently been surveyed in the course of an ongoing study of C2 agility conducted for the UK MOD. Whilst the accounts presented of agility differ widely, common to all of the...