The development of stent has been a major achievement in treating obstructive coronary artery disease (OCAD). The main obstacle in the long term success of percutaneous coronary intervention (PCI) was the neo-intimal hyperplasia developed within the stent, which may leads to instent restenosis. The introduction of Drug-eluting stents (DES) shows steep decrease in angiographic restenosis when co...

OBJECTIVE Intracoronary stenting was designed to overcome acute complications after percutaneous transluminal coronary angioplasty and to achieve a reduced rate of restenosis, both of which are major limitations of this well accepted method for treating coronary heart disease. This report describes the experience at one centre with the implantation of balloon-expandable Palmaz-Schatz stents and...

I n-stent restenosis and the need of repeat revascularisation remain the major limitations of coronary angioplasty for patients with multivessel disease. 2 Utilisation of drug eluting stents in this context is expected to have a major impact on the effectiveness of percutaneous treatment. Sirolimus eluting stent implantation has recently been shown to significantly reduce coronary restenosis, w...

Before coronary stents, balloon angioplasty was limited by arterial dissection, acute closure, Q-wave myocardial infarction (MI), a 5% risk for emergency coronary artery bypass graft surgery, the need for repeat procedures to treat restenosis, and sometimes procedural death. Coronary stents immediately reduced those major procedural complications. The current debates about asymptomatic periproc...

BACKGROUND Coronary artery stents are used for the treatment of acute or threatening vessel occlusion complicating coronary angioplasty or for prevention of restenosis after angioplasty. The current randomized trial compared the procedural outcome and long-term patency of 2 different flexible stents in unselected lesion morphology. METHODS The study population consisted of consecutive patient...

Background: The incidence of restenosis in patients suffering from coronary artery disease after undergoing angioplasty is of paramount importance. Accordingly, this study aimed to investigate factors affecting the time of the first incidence of restenosis in patients undergone angioplasty in the city of Zanjan, Iran.   Methods: This retrospective cohort study was conducted on 421 patie...

BACKGROUND Lesions in small-diameter vessels (<3 mm) define a group with distinct clinical and morphological characteristics. There is an inverse relationship between vessel size and angiographic restenosis rate. This study assessed whether stents reduce angiographic restenosis in small coronary arteries compared with standard balloon angioplasty. METHODS AND RESULTS We randomly assigned 351 ...

Percutaneous coronary intervention (PCI), which includes percutaneous transluminal coronary angioplasty (PTCA) and coronary stenting, has continued expanding its role in the management of coronary atherosclerosis. Major advances in the technical aspects of PCI (especially coronary stents) have had a favorable impact on both early and long-term outcomes (1 ). Although bare-metal stents have dram...

Coronary artery disease (CAD) has been reported to be a major cause of death worldwide. Current treatment methods include atherectomy, coronary angioplasty (as a percutaneous coronary intervention), and coronary artery bypass. Among them, the insertion of stents into the coronary artery is one of the commonly used methods for CAD, although the formation of in-stent restenosis (ISR) is a major d...

Balloon angioplasty revolutionized coronary revascularization; however, elastic recoil and restenosis caused by cellular proliferation are major drawbacks of angioplasty. Intracoronary stenting, which could tackle dissections and eliminate elastic recoil, became the next mode of intervention but was limited by stent thrombosis and increased neointimal hyperplasia, leading to in-stent restenosis...